What is aTyr Pharma's net margin?

aTyr Pharma (ATYR) reported net margin of -39,009.5% in Q4 2025.

How has aTyr Pharma's net margin changed year-over-year?

aTyr Pharma's net margin decreased by 43.2% year-over-year, from -27,243.8% to -39,009.5%.

What is the long-term trend for aTyr Pharma's net margin?

Over 3 years (2020 to 2025), aTyr Pharma's net margin has grown at a 531.1% compound annual growth rate (CAGR), from -155.2% to -39,009.5%.

What does net margin mean?

Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.

aTyr Pharma ATYR Net margin

Net margin at other companies

Bristol-Myers SquibbBMY

15%+3.8pp

Merck & Co.MRK

13.6%-13.7pp

United TherapeuticsUTHR

40.6%+0.2pp

Syndax PharmaceuticalsSNDX

-111.9%-51.5pp

Stoke Therapeutics, Inc.STOK

-529.2%-556pp

ZymeworksZYME

-126.3%+5.0pp

Other financials

Income statement

See full

Revenue-—

Operating income-$11.4M+27.5%

Net income-$10.8M+27.5%

EPS (diluted)-$0.11+35.3%

Balance sheet

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Cash & equivalents$10.0M-3.4%

Total debt$12.3M-9.2%

Total equity$57.9M-22.8%

Total assets$79.7M-18.1%

Cash flow

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Operating cash flow-$12.5M+18.8%

CapEx$138.0K—

Free cash flow-$12.7M+17.9%

Valuation

See full

Market cap$54.88M-88.2%

Enterprise value$57.17M—

P/S288.8×—

Profitability

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Operating margin-40,856.3%+28,833pp

FCF margin-32,664.7%+4,018pp

Returns & leverage

See full

Return on equity-105.3%+50.6pp

Debt / equity0.2×0.0×

Current ratio5.8×-2.0×

Where this comes from

Calculated from aTyr Pharma’s reported figures.

net income/total revenue=-39,009.5%

Based on trailing twelve months.

The official record: aTyr Pharma’s 10-Q, filed May 15, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is aTyr Pharma's net margin?: aTyr Pharma (ATYR) reported net margin of -39,009.5% in Q4 2025.
How has aTyr Pharma's net margin changed year-over-year?: aTyr Pharma's net margin decreased by 43.2% year-over-year, from -27,243.8% to -39,009.5%.
What is the long-term trend for aTyr Pharma's net margin?: Over 3 years (2020 to 2025), aTyr Pharma's net margin has grown at a 531.1% compound annual growth rate (CAGR), from -155.2% to -39,009.5%.
What does net margin mean?: Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.