What is Stoke Therapeutics, Inc.'s net margin?

Stoke Therapeutics, Inc. (STOK) reported net margin of -529.2% in Q1 2026.

How has Stoke Therapeutics, Inc.'s net margin changed year-over-year?

Stoke Therapeutics, Inc.'s net margin decreased by 2109.6% year-over-year, from 26.3% to -529.2%.

What is the long-term trend for Stoke Therapeutics, Inc.'s net margin?

Over 3 years (2022 to 2025), Stoke Therapeutics, Inc.'s net margin has grown at a -83.4% compound annual growth rate (CAGR), from -814.8% to -3.7%.

What does net margin mean?

Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.

Stoke Therapeutics, Inc. STOK Net margin

Net margin at other companies

Ionis PharmaceuticalsIONS

-30.9%-10.5pp

Jazz PharmaceuticalsJAZZ

-8.9%-20.5pp

Xenon PharmaceuticalsXENE

-4,612.1%—

Praxis Precision Medicines, Inc.PRAX

-3,658.5%-1,388pp

Harmony Biosciences Holdings, Inc.HRMY

16.2%-4.3pp

Nurix Therapeutics, Inc.NRIX

-411.4%+52.7pp

Other financials

Income statement

See full

Revenue$6.2M-96.1%

Operating income-$53.4M-148%

Net income-$50.0M-144%

EPS (diluted)-$0.79-142%

Balance sheet

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Cash & equivalents$155.7M-43.4%

Total debt$3.4M-42.5%

Total equity$394.9M+12.8%

Total assets$443.3M+8.9%

Cash flow

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Operating cash flow-$60.6M-146%

CapEx$353.0K+132%

Free cash flow-$60.9M-146%

Valuation

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Market cap$1.94B+436%

Enterprise value$1.79B+1,855%

P/S60.4×+58.5×

Profitability

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Operating margin-577.5%-597pp

FCF margin36.2%+18.4pp

Returns & leverage

See full

Return on equity-45.6%-66.1pp

Debt / equity0×0.0×

Current ratio9×+0.6×

Where this comes from

Calculated from Stoke Therapeutics, Inc.’s reported figures.

net income/total revenue=-529.2%

Based on trailing twelve months.

The official record: Stoke Therapeutics, Inc.’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Stoke Therapeutics, Inc.'s net margin?: Stoke Therapeutics, Inc. (STOK) reported net margin of -529.2% in Q1 2026.
How has Stoke Therapeutics, Inc.'s net margin changed year-over-year?: Stoke Therapeutics, Inc.'s net margin decreased by 2109.6% year-over-year, from 26.3% to -529.2%.
What is the long-term trend for Stoke Therapeutics, Inc.'s net margin?: Over 3 years (2022 to 2025), Stoke Therapeutics, Inc.'s net margin has grown at a -83.4% compound annual growth rate (CAGR), from -814.8% to -3.7%.
What does net margin mean?: Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.