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Stoke Therapeutics, Inc.

STOK

Stoke Therapeutics is a late-stage clinical biotechnology company focused on treating severe genetic diseases by upregulating protein expression using RNA-based medicines.

Market cap
$2.03B+224%
Revenue$32.1M-83.2%
Net income-$169.8M-438%
Free cash flow$25.8M+132%
EPS (diluted)-$2.81-451%
Trailing twelve months · change vs. prior year

Earnings

Next report

Aug 11, 2026 (in a month)
Revenue estimate$5.4M
EPS estimate-$0.82

Financials

Q1 2026

Income statement

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Revenue$6.2M-96.1%
Operating income-$53.4M-148%
Net income-$50.0M-144%
EPS (diluted)-$0.79-142%

Balance sheet

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Cash & equivalents$155.7M-43.4%
Total debt$3.4M-42.5%
Total equity$394.9M+12.8%
Total assets$443.3M+8.9%

Cash flow

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Operating cash flow-$60.6M-146%
CapEx$353.0K+132%
Free cash flow-$60.9M-146%

Valuation & ratios

Valuation

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Market cap$2.03B+224%
Enterprise value$1.88B+255%
P/S63.4×+60.3×

Profitability

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Operating margin-577.5%-597pp
Net margin-529.2%-556pp

Returns & leverage

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Return on equity-45.6%-66.1pp
Debt / equity0.0×
Current ratio+0.6×

Competitors

Profile

Stoke Therapeutics is a late-stage clinical biotechnology company focused on treating severe genetic diseases by upregulating protein expression using RNA-based medicines. The company utilizes its proprietary TANGO platform to develop antisense oligonucleotides that restore functional protein levels in patients with haploinsufficiencies, where one gene copy is mutated. Their lead programs target life-altering conditions of the central nervous system and the eye.

Competitive position

A pioneer in developing disease-modifying therapies for haploinsufficiencies using a proprietary RNA-based upregulation platform (TANGO).

GeographiesUnited States, United Kingdom, European Union, Japan, Canada, Mexico
Customer segmentsPediatric patients, Neurology patients, Ophthalmology patients
Business modelR&D-stage biotechnology, Licensing and Collaboration
SuppliersContract Manufacturing Organizations (CMOs), Raw material suppliers for oligonucleotides, Academic research institutions, Clinical trial sites
CustomersSpecialized treatment centers, Healthcare providers, Biopharmaceutical licensees
Listed2019
Employees110.0
CEOIan F. Smith
FilingsSEC EDGAR

Questions, answered.

What is Stoke Therapeutics, Inc.'s market cap?
Stoke Therapeutics, Inc. (STOK) has a market capitalization of $2.0B and trades on NASDAQ.
What is Stoke Therapeutics, Inc.'s revenue and profitability?
Stoke Therapeutics, Inc. generated $32.1M in trailing twelve-month revenue with a net loss of $169.8M, representing a net margin of -529.2%, with free cash flow of $25.8M. These figures are based on the Q1 2026 filing.
Who are Stoke Therapeutics, Inc.'s competitors?
Stoke Therapeutics, Inc.'s key competitors include Ionis Pharmaceuticals, Jazz Pharmaceuticals, Xenon Pharmaceuticals, and others. These companies compete in similar markets and product categories.
Who does Stoke Therapeutics, Inc. partner with?
Stoke Therapeutics, Inc.'s notable partners include Biogen, Acadia Pharmaceuticals Inc., University of Southampton.
Where is Stoke Therapeutics, Inc. headquartered?
Stoke Therapeutics, Inc. is headquartered in United States of America and employs approximately 110 people. It has been publicly traded since 2019.