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Operating margin at other companies

Ionis Pharmaceuticals logo
Ionis PharmaceuticalsIONS
-33.3%-11.0pp
Jazz Pharmaceuticals logo
Jazz PharmaceuticalsJAZZ
-11.9%-28.1pp
Xenon Pharmaceuticals logo
Xenon PharmaceuticalsXENE
-4,974.3%
Praxis Precision Medicines, Inc. logo
Praxis Precision Medicines, Inc.PRAX
-3,927.5%-1,497pp
Harmony Biosciences Holdings, Inc. logo
Harmony Biosciences Holdings, Inc.HRMY
21.1%-5.1pp
Nurix Therapeutics, Inc. logo
Nurix Therapeutics, Inc.NRIX
-439.3%+35.3pp

Other financials

Income statement

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Revenue$6.2M-96.1%
Operating income-$53.4M-148%
Net income-$50.0M-144%
EPS (diluted)-$0.79-142%

Balance sheet

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Cash & equivalents$155.7M-43.4%
Total debt$3.4M-42.5%
Total equity$394.9M+12.8%
Total assets$443.3M+8.9%

Cash flow

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Operating cash flow-$60.6M-146%
CapEx$353.0K+132%
Free cash flow-$60.9M-146%

Valuation

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Market cap$1.94B+436%
Enterprise value$1.79B+1,855%
P/S60.4×+58.5×

Profitability

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Net margin-529.2%-556pp
FCF margin36.2%+18.4pp

Returns & leverage

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Return on equity-45.6%-66.1pp
Debt / equity0.0×
Current ratio+0.6×

Where this comes from

Calculated from Stoke Therapeutics, Inc.’s reported figures.

Based on trailing twelve months.

The official record: Stoke Therapeutics, Inc.’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Stoke Therapeutics, Inc.'s operating margin?
Stoke Therapeutics, Inc. (STOK) reported operating margin of -577.5% in Q1 2026.
How has Stoke Therapeutics, Inc.'s operating margin changed year-over-year?
Stoke Therapeutics, Inc.'s operating margin decreased by 2982.7% year-over-year, from 20% to -577.5%.
What is the long-term trend for Stoke Therapeutics, Inc.'s operating margin?
Over 3 years (2022 to 2025), Stoke Therapeutics, Inc.'s operating margin has grown at a -76.3% compound annual growth rate (CAGR), from -841.3% to -11.2%.
What does operating margin mean?
Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.