What is Xenon Pharmaceuticals's operating margin?

Xenon Pharmaceuticals (XENE) reported operating margin of -4,974.3% in Q4 2025.

What is the long-term trend for Xenon Pharmaceuticals's operating margin?

Over 3 years (2020 to 2025), Xenon Pharmaceuticals's operating margin has grown at a 271.1% compound annual growth rate (CAGR), from -97.3% to -4,974.3%.

What does operating margin mean?

Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.

Xenon Pharmaceuticals XENE Operating margin

Operating margin at other companies

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26.4%+2.8pp

Jazz PharmaceuticalsJAZZ

-11.9%-28.1pp

Axsome TherapeuticsAXSM

-24.4%-9.3pp

Praxis Precision Medicines, Inc.PRAX

-3,927.5%-1,497pp

Neurocrine BiosciencesNBIX

25.4%+4.9pp

BridgeBio PharmaBBIO

-90.5%-41.2pp

Other financials

Income statement

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Revenue--100%

Operating income-$112.3M-54.4%

Net income-$102.3M-57.3%

EPS (diluted)-$1.17-41.0%

Balance sheet

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Cash & equivalents$545.9M+368%

Total debt$7.5M-13.6%

Total equity$1.3B+90.0%

Total assets$1.4B+86.6%

Cash flow

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Operating cash flow-$88.9M-44.2%

CapEx$133.0K+209%

Free cash flow-$89.0M-44.3%

Valuation

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Market cap$5.11B+116%

Enterprise value$4.58B+104%

Profitability

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Net margin-4,612.1%—

FCF margin-3,732.2%—

Returns & leverage

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Return on equity-37.5%+8.7pp

Debt / equity0×0.0×

Current ratio27.8×+10.1×

Where this comes from

Calculated from Xenon Pharmaceuticals’s reported figures.

operating income/total revenue=-4,974.3%

Based on trailing twelve months.

The official record: Xenon Pharmaceuticals’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Xenon Pharmaceuticals's operating margin?: Xenon Pharmaceuticals (XENE) reported operating margin of -4,974.3% in Q4 2025.
What is the long-term trend for Xenon Pharmaceuticals's operating margin?: Over 3 years (2020 to 2025), Xenon Pharmaceuticals's operating margin has grown at a 271.1% compound annual growth rate (CAGR), from -97.3% to -4,974.3%.
What does operating margin mean?: Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.