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Septerna, Inc.

SEPN

Septerna is a clinical-stage biotechnology company focused on discovering and developing oral small molecule drugs targeting G protein-coupled receptors (GPCRs).

Market cap
$1.71B+228%
Revenue$72.3M+7,296%
Net income-$36.0M+54.5%
Free cash flow$98.3M+241%
EPS (diluted)-$0.81+96.4%
Trailing twelve months · change vs. prior year

Earnings

Next report

Aug 10, 2026 (In 4 weeks)
Revenue estimate$19.2M
EPS estimate-$0.48

Financials

Q1 2026

Income statement

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Revenue$26.5M+12,011%
Operating income-$13.3M+48.7%
Net income-$8.6M+59.8%
EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%
Total debt$23.1M-7.7%
Total equity$378.5M+195%
Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%
CapEx$832.0K+118%
Free cash flow-$26.5M-11.5%

Valuation & ratios

Valuation

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Market cap$1.71B+228%
Enterprise value$1.66B+420%
P/S23.6×-642×

Profitability

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Operating margin-77.1%-38.4pp
Net margin-49.9%-24.9pp

Returns & leverage

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Debt / equity0.1×
Current ratio4.7×-27.5×

Competitors

Profile

Septerna is a clinical-stage biotechnology company focused on discovering and developing oral small molecule drugs targeting G protein-coupled receptors (GPCRs). Utilizing its proprietary Native Complex Platform, the company aims to unlock the therapeutic potential of the approximately 75% of GPCR targets that remain undrugged. Its primary value proposition lies in replicating the native functional form of GPCRs outside of cells to enable industrialized, structure-based drug design for endocrine, metabolic, and inflammatory diseases.

Competitive position

Septerna is a pioneer in GPCR drug discovery, utilizing a first-of-its-kind platform to isolate and reconstitute GPCR proteins in their native functional form for industrial-scale drug design.

GeographiesUnited States, Australia, Europe
Customer segmentsPatients, Strategic Partners
Business modelR&D, IP Licensing
SuppliersContract Manufacturing Organizations (CMOs), Academic research institutions, Specialized laboratory equipment providers
CustomersStrategic pharmaceutical partners, Healthcare providers, Patients with endocrine and metabolic disorders
Listed2024
CEOJeffrey T. Finer
FilingsSEC EDGAR

Questions, answered.

What is Septerna, Inc.'s market cap?
Septerna, Inc. (SEPN) has a market capitalization of $1.7B and trades on XNAS.
What is Septerna, Inc.'s revenue and profitability?
Septerna, Inc. generated $72.3M in trailing twelve-month revenue with a net loss of $36.0M, representing a net margin of -49.9%, with free cash flow of $98.3M. These figures are based on the Q1 2026 filing.
Who are Septerna, Inc.'s competitors?
Septerna, Inc.'s key competitors include Structure Therapeutics, Tectonic Therapeutic, Amgen, and others. These companies compete in similar markets and product categories.
Who does Septerna, Inc. partner with?
Septerna, Inc.'s notable partners include Novo Nordisk A/S, Ascendis Pharma.
Where is Septerna, Inc. headquartered?
Septerna, Inc. is headquartered in United States of America. It has been publicly traded since 2024.