What is Septerna, Inc.'s operating margin?

Septerna, Inc. (SEPN) reported operating margin of -77.1% in Q1 2026.

How has Septerna, Inc.'s operating margin changed year-over-year?

Septerna, Inc.'s operating margin increased by 99.2% year-over-year, from -9,339.1% to -77.1%.

What does operating margin mean?

Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.

Septerna, Inc. SEPN Operating margin

Operating margin at other companies

AmgenAMGN

28.4%+6.6pp

Stoke Therapeutics, Inc.STOK

-577.5%-597pp

Nurix Therapeutics, Inc.NRIX

-439.3%+35.3pp

Fortrea Holdings Inc.FTRE

-13.1%-4.1pp

PrecigenPGEN

-2,890.9%—

Catalyst PharmaceuticalCPRX

44.8%+1.6pp

Other financials

Income statement

See full

Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

See full

Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

See full

Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

See full

Market cap$1.65B+319%

Enterprise value$1.6B+1,325%

P/S22.8×-379×

Profitability

See full

Net margin-49.9%-24.9pp

FCF margin467.9%+243pp

Returns & leverage

See full

Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

operating income/total revenue=-77.1%

Based on trailing twelve months.

The official record: Septerna, Inc.’s 10-Q, filed May 11, 2026, on SEC EDGAR. View the filing →

Ask your AI about Septerna, Inc.'s operating margin.

Connect your AI assistant and compare it to peers, right in your chat.

Connect your AI

Claude

Questions, answered.

What is Septerna, Inc.'s operating margin?: Septerna, Inc. (SEPN) reported operating margin of -77.1% in Q1 2026.
How has Septerna, Inc.'s operating margin changed year-over-year?: Septerna, Inc.'s operating margin increased by 99.2% year-over-year, from -9,339.1% to -77.1%.
What does operating margin mean?: Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.