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Septerna, Inc. SEPN Operating margin

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Other financials

Income statement

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Revenue$26.5M+12,011%
Operating income-$13.3M+48.7%
Net income-$8.6M+59.8%
EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%
Total debt$23.1M-7.7%
Total equity$378.5M+195%
Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%
CapEx$832.0K+118%
Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.78B+240%
Enterprise value$1.73B+383%
P/S24.7×-696×

Profitability

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Net margin-49.9%-24.9pp
FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%
Debt / equity0.1×
Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

Based on trailing twelve months.

The source filing: Septerna, Inc.’s 10-Q, filed May 11, 2026. Open the filing →

Filed
May 11, 2026, 4:08 PM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001193125-26-216759

FAQ

What is Septerna, Inc.'s operating margin?
Septerna, Inc. (SEPN) reported operating margin of -77.1% in Q1 2026.
How has Septerna, Inc.'s operating margin changed year-over-year?
Septerna, Inc.'s operating margin increased by 99.2% year-over-year, from -9,339.1% to -77.1%.
What does operating margin mean?
Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.

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