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Septerna, Inc. SEPN Ratios & Valuation

Q2 '26Q1 '26Q4 '25Q3 '25Q2 '25
Profitability
Operating margin-44%+14,027pp-77.1%+9,262pp-148.6%+7,370pp-349.2%+1,872pp-14,071.1%-12,725pp
Net margin-24.5%+12,029pp-49.9%+8,054pp-106.4%+6,573pp-266.8%+1,388pp-12,053%-11,259pp
Returns
Return on equity-6.3%—-9.3%—-12.2%—————
Return on invested capital-16.2%—-20.4%—-27.8%—————
Efficiency
Asset turnover0.2×—0.1×—0.1×+0.1×0.1×———
Liquidity
Current ratio5×-17.1×4.7×-27.5×4.7×-23.0×6.5×-3.6×22.1×—
Leverage
Debt-to-equity0.1×0.0×0.1×0.0×0.1×0.0×0.1×—0.1×—
Per Share
Book value per share$8.59+0.4%$8.46-7.2%$8.63-79.7%$8.52+124%$8.55+129%
Valuation
Market capitalization$1.78B+97.7%$1.08B+319%$1.25B+22.8%$838.65M—$477.22M—
Price / sales18×-22.8×14.9×-248×27.2×-919×38×—657.3×—
Price / book4.6×+2.3×2.9×+2.2×3.3×+0.8×2.2×—1.3×—

FAQ

Where do Septerna, Inc.'s ratios come from?
Every ratio is computed from Septerna, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.