Skip to content

Septerna, Inc. SEPN Return on invested capital

Return on invested capital at other companies

Amgen logo
AmgenAMGN
14.1%+4.0pp
Stoke Therapeutics, Inc. logo
Stoke Therapeutics, Inc.STOK
-114.4%
Nurix Therapeutics, Inc. logo
Nurix Therapeutics, Inc.NRIX
-70.2%-7.5pp
Rapport Therapeutics, Inc. logo
Rapport Therapeutics, Inc.RAPP
-38.2%
Fortrea Holdings Inc. logo
Fortrea Holdings Inc.FTRE
-20.1%-3.1pp
Precigen logo
PrecigenPGEN
-204.2%-592pp

Other financials

Income statement

See full
Revenue$26.5M+12,011%
Operating income-$13.3M+48.7%
Net income-$8.6M+59.8%
EPS (diluted)-$0.19+61.2%

Balance sheet

See full
Cash & equivalents$71.6M-65.9%
Total debt$23.1M-7.7%
Total equity$378.5M+195%
Total assets$569.7M+31.3%

Cash flow

See full
Operating cash flow-$25.6M-9.8%
CapEx$832.0K+118%
Free cash flow-$26.5M-11.5%

Valuation

See full
Market cap$1.62B+319%

Profitability

See full
Operating margin-77.1%-38.4pp
Net margin-49.9%-24.9pp
FCF margin467.9%+243pp

Returns & leverage

See full
Return on equity-12.2%
Debt / equity0.1×
Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

Based on trailing twelve months.

The official record: Septerna, Inc.’s 10-Q, filed May 11, 2026, on SEC EDGAR. View the filing →

Ask your AI about Septerna, Inc.'s return on invested capital.

Connect your AI assistant and compare it to peers, right in your chat.

Connect your AI
Harbor at dusk
Claude

Questions, answered.

What is Septerna, Inc.'s return on invested capital?
Septerna, Inc. (SEPN) reported return on invested capital of -27.8% in Q4 2025.
What does return on invested capital mean?
Net operating profit after tax (operating income taxed at the effective rate) divided by average invested capital (debt plus equity minus cash). Measures the after-tax return on all capital put to work in the business, independent of capital structure.