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Septerna, Inc. SEPN Operating Cash Flow

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Other financials

Income statement

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Revenue$26.5M+12,011%
Operating income-$13.3M+48.7%
Net income-$8.6M+59.8%
EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%
Total debt$23.1M-7.7%
Total equity$378.5M+195%
Total assets$569.7M+31.3%

Cash flow

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CapEx$832.0K+118%
Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.78B+240%
Enterprise value$1.73B+383%
P/S24.7×-696×

Profitability

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Operating margin-77.1%-38.4pp
Net margin-49.9%-24.9pp
FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%
Debt / equity0.1×
Current ratio4.7×-27.5×

Where this comes from

Reported directly by Septerna, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities.

The source filing: Septerna, Inc.’s 10-Q, filed May 11, 2026.

Filed
May 11, 2026, 4:08 PM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001193125-26-216759
Line itemThree Months Ended March 31, 2026Three Months Ended March 31, 2025
Deferred revenue(16,239)
Operating lease, net(535)(450)
Other non-current liabilities100
Net cash used in operating activities(25,633)(23,343)
Cash flows from investing activities:
Purchases of property and equipment(832)(382)
Purchases of marketable securities(105,230)(49,715)
Maturities of marketable securities82,24545,223

Item 1. Condensed Financial Statements.

FAQ

What is Septerna, Inc.'s operating cash flow?
Septerna, Inc. (SEPN) reported operating cash flow of -$25.63M in Q1 2026.
How has Septerna, Inc.'s operating cash flow changed year-over-year?
Septerna, Inc.'s operating cash flow decreased by 9.8% year-over-year, from -$23.34M to -$25.63M.
What does operating cash flow mean?
Total cash generated by or used in core business operations — the single most important cash flow metric for assessing business health.

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