What is Septerna, Inc.'s free cash flow margin?

Septerna, Inc. (SEPN) reported free cash flow margin of 467.9% in Q3 2025.

How has Septerna, Inc.'s free cash flow margin changed year-over-year?

Septerna, Inc.'s free cash flow margin increased by 107.9% year-over-year, from -5,916.3% to 467.9%.

What does free cash flow margin mean?

Free cash flow (operating cash flow minus capital expenditures) as a percentage of revenue, trailing twelve months. Measures how efficiently revenue converts into discretionary cash.

Septerna, Inc. SEPN Free cash flow margin

Free cash flow margin at other companies

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23.1%-8.9pp

Stoke Therapeutics, Inc.STOK

36.2%+18.4pp

Nurix Therapeutics, Inc.NRIX

-378.7%+24.1pp

Fortrea Holdings Inc.FTRE

5.8%+1.7pp

PrecigenPGEN

-1,756.5%—

Catalyst PharmaceuticalCPRX

34.9%-15.2pp

Other financials

Income statement

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Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.65B+319%

Enterprise value$1.6B+1,325%

P/S22.8×-379×

Profitability

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Operating margin-77.1%-38.4pp

Net margin-49.9%-24.9pp

Returns & leverage

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Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

free cash flow/total revenue=467.9%

Based on trailing twelve months.

The official record: Septerna, Inc.’s 10-Q, filed November 10, 2025, on SEC EDGAR. View the filing →

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Questions, answered.

What is Septerna, Inc.'s free cash flow margin?: Septerna, Inc. (SEPN) reported free cash flow margin of 467.9% in Q3 2025.
How has Septerna, Inc.'s free cash flow margin changed year-over-year?: Septerna, Inc.'s free cash flow margin increased by 107.9% year-over-year, from -5,916.3% to 467.9%.
What does free cash flow margin mean?: Free cash flow (operating cash flow minus capital expenditures) as a percentage of revenue, trailing twelve months. Measures how efficiently revenue converts into discretionary cash.