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Septerna, Inc. SEPN Operating Income

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Other financials

Income statement

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Revenue$26.5M+12,011%
Net income-$8.6M+59.8%
EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%
Total debt$23.1M-7.7%
Total equity$378.5M+195%
Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%
CapEx$832.0K+118%
Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.78B+240%
Enterprise value$1.73B+383%
P/S24.7×-696×

Profitability

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Operating margin-77.1%-38.4pp
Net margin-49.9%-24.9pp
FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%
Debt / equity0.1×
Current ratio4.7×-27.5×

Where this comes from

Reported directly by Septerna, Inc. in its filing.

Tagged under the XBRL concept us-gaap:OperatingIncomeLoss.

The source filing: Septerna, Inc.’s 10-Q, filed May 11, 2026.

Filed
May 11, 2026, 4:08 PM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001193125-26-216759
Line itemThree Months Ended March 31, 2026Three Months Ended March 31, 2025
Research and development29,53519,271
General and administrative10,2886,858
Total operating expenses39,82326,129
Loss from operations(13,300)(25,910)
Other income, net:
Interest income5,0314,462
Other expense, net(31)(28)
Total other income, net5,0004,434

Item 1. Condensed Financial Statements.

FAQ

What is Septerna, Inc.'s operating income?
Septerna, Inc. (SEPN) reported operating income of -$13.3M in Q1 2026.
How has Septerna, Inc.'s operating income changed year-over-year?
Septerna, Inc.'s operating income increased by 48.7% year-over-year, from -$25.91M to -$13.3M.
What does operating income mean?
Gross profit minus all operating expenses (SG&A, R&D, D&A). Measures the profit from core business operations before interest, taxes, and non-operating items.

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