What are Iovance Biotherapeutics, Inc.'s profit margins?

Iovance Biotherapeutics, Inc. (IOVA) runs a 36.7% gross margin and a -127.2% operating margin, with a -123.9% net margin.

Where do Iovance Biotherapeutics, Inc.'s ratios come from?

Every ratio is computed from Iovance Biotherapeutics, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Iovance Biotherapeutics, Inc. IOVA Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	36.7%+4.1pp	31.3%-2.9pp	29.9%+1.2pp	30.2%+44.9pp	32.6%+368pp
Operating margin	-127.2%+60.3pp	-153.1%+87.8pp	-166.3%+307pp	-170%+1,231pp	-187.5%+24,362pp
Net margin	-123.9%+52.6pp	-148.4%+78.5pp	-158.8%+292pp	-161.4%+1,182pp	-176.5%+23,439pp
Returns
Return on equity	-47.5%+4.3pp	-55.5%+2.0pp	-53.9%+2.8pp	-53.2%+12.2pp	-51.8%+14.9pp
Return on invested capital	-59.5%+2.9pp	-65.2%+4.6pp	-65.2%+12.9pp	-66.6%+27.3pp	-62.4%+49.4pp
Efficiency
Asset turnover	0.3×+0.1×	0.3×+0.1×	0.3×+0.2×	0.3×+0.2×	0.2×+0.2×
Liquidity
Current ratio	3.6×-0.6×	3.2×-0.5×	3.4×-0.8×	3.3×-1.9×	4.2×-0.5×
Leverage
Debt-to-equity	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×-0.1×
Per Share
Book value per share	$1.72-27.5%	$1.95-20.2%	——	$2.09-22.6%	$2.38-6.9%
Valuation
Market capitalization	$1.45B+32.4%	$1.08B-51.9%	$785.22M-70.6%	$627.8M-70.6%	$1.09B-71.2%
Price / sales	5.1×-0.1×	4.1×-9.6×	3.1×-26.3×	2.6×-62.6×	5.1×-1,987×
Price / book	2×+0.6×	1.6×-1.6×	1.1×-2.3×	0.9×-1.9×	1.4×-4.2×

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Questions, answered.

What are Iovance Biotherapeutics, Inc.'s profit margins?: Iovance Biotherapeutics, Inc. (IOVA) runs a 36.7% gross margin and a -127.2% operating margin, with a -123.9% net margin.
Where do Iovance Biotherapeutics, Inc.'s ratios come from?: Every ratio is computed from Iovance Biotherapeutics, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.