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Protagonist Therapeutics

PTGX

Protagonist Therapeutics is an integrated biotechnology company that utilizes a proprietary technology platform to discover and develop novel peptide-based therapies.

Market cap
$8.72B+158%
Revenue$74.1M-64.4%
Net income-$114.7M-304%
Free cash flow$316.6M+365%
EPS (diluted)-$1.82-333%
Trailing twelve months · change vs. prior year

Earnings

Next report

Aug 5, 2026 (In 1 week)
Revenue estimate$199.8M
EPS estimate$2.11

Financials

Q1 2026

Income statement

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Revenue$56.4M+99.0%
Operating income-$3.6M+81.1%
Net income$3.8M+132%
EPS (diluted)$0.05+126%

Balance sheet

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Cash & equivalents$193.7M+38.7%
Total debt$9.8M-13.9%
Total equity$655.5M-4.9%
Total assets$697.5M-6.0%

Cash flow

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Operating cash flow-$48.9M-139%
CapEx$215.0K-60.6%
Free cash flow-$49.2M-139%

Valuation & ratios

Valuation

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Market cap$8.72B+158%
Enterprise value$8.53B+156%
P/S117.7×+101×

Profitability

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Operating margin-192.4%-205pp
Net margin-154.9%-182pp

Returns & leverage

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Return on equity-17.1%-26.1pp
Debt / equity0.0×
Current ratio17.8×+0.5×

Segments

By segment

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Single Reportable$56.4M+99.0%

Competitors

Profile

Protagonist Therapeutics is an integrated biotechnology company that utilizes a proprietary technology platform to discover and develop novel peptide-based therapies. The company focuses on creating targeted medicines for biologically validated pathways in inflammation, immunology, hematology, and metabolic diseases. Its core value proposition lies in developing oral and injectable alternatives to existing parenteral biologic treatments to improve patient adherence and clinical outcomes.

Competitive position

A platform-driven innovator specializing in converting injectable biologic pathways into oral peptide therapeutics, supported by high-profile global pharmaceutical partnerships.

GeographiesUnited States, Europe, Global
Customer segmentsBiopharmaceutical Companies, Specialty Healthcare Providers
Business modelR&D, Licensing and Royalties, Collaborative Development
SuppliersContract Research Organizations (CROs), Raw material suppliers for peptide synthesis, Clinical trial sites
CustomersJanssen Biotech (Johnson & Johnson), Takeda Pharmaceuticals, Specialty pharmacies, Hospitals and clinics
Listed2016
Employees124.0
CEODinesh V. Patel
FilingsSEC EDGAR

Questions, answered.

What is Protagonist Therapeutics's market cap?
Protagonist Therapeutics (PTGX) has a market capitalization of $8.7B and trades on NASDAQ.
What is Protagonist Therapeutics's revenue and profitability?
Protagonist Therapeutics generated $74.1M in trailing twelve-month revenue with a net loss of $114.7M, representing a net margin of -154.9%, with free cash flow of $316.6M. These figures are based on the Q1 2026 filing.
Who are Protagonist Therapeutics's competitors?
Protagonist Therapeutics's key competitors include Incyte, Eli Lilly and Company, Amgen, and others. These companies compete in similar markets and product categories.
Who does Protagonist Therapeutics partner with?
Protagonist Therapeutics's notable partners include Janssen Biotech, Inc., Takeda Pharmaceuticals, Inc..
Where is Protagonist Therapeutics headquartered?
Protagonist Therapeutics is headquartered in United States of America and employs approximately 124 people. It has been publicly traded since 2016.