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Operating margin at other companies

Amgen logo
AmgenAMGN
28.4%+6.6pp
Incyte logo
IncyteINCY
30%+26.1pp
AbbVie logo
AbbVieABBV
24.4%
Spyre Therapeutics, Inc. logo
Spyre Therapeutics, Inc.SYRE
-39,428.9%-49,795pp
Regeneron Pharmaceuticals logo
Regeneron PharmaceuticalsREGN
24.3%-2.9pp
Kymera Therapeutics logo
Kymera TherapeuticsKYMR
-697.7%+635pp

Other financials

Income statement

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Revenue$56.4M+99.0%
Operating income-$3.6M+81.1%
Net income$3.8M+132%
EPS (diluted)$0.05+126%

Balance sheet

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Cash & equivalents$193.7M+38.7%
Total debt$9.8M-13.9%
Total equity$655.5M-4.9%
Total assets$697.5M-6.0%

Cash flow

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Operating cash flow-$48.9M-139%
CapEx$215.0K-60.6%
Free cash flow-$49.2M-139%

Valuation

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Market cap$7.26B+127%
Enterprise value$7.07B+130%
P/S98×+82.6×

Profitability

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Net margin-154.9%-182pp
FCF margin-12,264.3%-12,527pp

Returns & leverage

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Return on equity-17.1%-26.1pp
Debt / equity0.0×
Current ratio17.8×+0.5×

Where this comes from

Calculated from Protagonist Therapeutics’s reported figures.

Based on trailing twelve months.

The official record: Protagonist Therapeutics’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Protagonist Therapeutics's operating margin?
Protagonist Therapeutics (PTGX) reported operating margin of -192.4% in Q1 2026.
How has Protagonist Therapeutics's operating margin changed year-over-year?
Protagonist Therapeutics's operating margin decreased by 1568.3% year-over-year, from 13.1% to -192.4%.
What is the long-term trend for Protagonist Therapeutics's operating margin?
Over 3 years (2021 to 2025), Protagonist Therapeutics's operating margin has grown at a -9.3% compound annual growth rate (CAGR), from -460% to -343.6%.
What does operating margin mean?
Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.