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Rhythm Pharmaceuticals, Inc. RYTM Q4 2025 Annual earnings

Reported February 26, 2026 · Before market open

Revenue$57.3MBeat by $1.0M
EPS-$0.73Beat by $0.06
Revenue estimate$56.2M
EPS estimate-$0.79

Next report

Aug 4, 2026 (In 6 days)
Revenue estimate$67.7M
EPS estimate-$0.82

Financials

Q4 2025

Income statement

See full
Revenue$57.3M+36.9%
Gross profit$52.5M+37.9%
Operating income-$47.1M-14.1%
Net income-$47.5M-9.7%
EPS (diluted)-$0.73-1.4%

Balance sheet

See full
Cash & equivalents$54.3M-39.1%
Total debt$112.2M-1.4%
Total equity$139.1M+540%
Total assets$480.2M+22.4%

Cash flow

See full
Operating cash flow-$25.4M-34.7%
CapEx$238.3K—
Free cash flow-$29.2M-2.4%

Valuation & ratios

Valuation

as of 12/31/25
See full
Market cap$7.14B+108%
Enterprise value$7.2B+108%
P/S37.6×+11.2×

Profitability

See full
Gross margin89.7%0.0pp
Operating margin-101.2%-33.9pp
Net margin-103.6%-33.7pp
FCF margin-61.5%-14.1pp

Returns & leverage

See full
Return on equity-244.5%-22.6pp
Debt / equity0.8×-4.4×
Current ratio4.4×+1.2×

Segments

By segment

See full
Single reportable segment$57.3M+36.9%

Versus estimates

Revenue

Q1 2026$60.1MBeat by $4.3M
Q4 2025$57.3MBeat by $1.0M
Q3 2025$51.3MMiss by $4.7MQ2 2025$48.5MMiss by $2.8MQ1 2025$32.7MMiss by $10.6MQ4 2024$41.8MBeat by $3.3M

Diluted EPS

Q1 2026-$0.83Beat by $0.03
Q4 2025-$0.73Beat by $0.06
Q3 2025-$0.82Miss by $0.10Q2 2025-$0.75Miss by $0.09Q1 2025-$0.81Miss by $0.12Q4 2024-$0.72Miss by $0.03

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Questions, answered.

When did Rhythm Pharmaceuticals, Inc. report Q4 2025 earnings?
Rhythm Pharmaceuticals, Inc. (RYTM) reported Q4 2025 earnings on February 26, 2026 before market open.
What were Rhythm Pharmaceuticals, Inc.'s Q4 2025 revenue and EPS?
Rhythm Pharmaceuticals, Inc. reported revenue of $57.3M and eps of $-0.73 for Q4 2025.
Did Rhythm Pharmaceuticals, Inc. beat estimates in Q4 2025?
Revenue beat the consensus estimate of $56.2M by $1.0M. EPS beat the consensus estimate of $-0.79 by $0.06.
How did Rhythm Pharmaceuticals, Inc.'s Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 36.9% from $41.8M a year earlier and eps declined 1.4% from $-0.72.
Where can I find Rhythm Pharmaceuticals, Inc.'s Q4 2025 SEC filings?
You can read the 8-K earnings release (0001628280-26-011987) and the 10-K periodic report (0001628280-26-012399) directly on SEC EDGAR. The filing index links above go to sec.gov.