What is Zymeworks's net margin?

Zymeworks (ZYME) reported net margin of -126.3% in Q1 2026.

How has Zymeworks's net margin changed year-over-year?

Zymeworks's net margin decreased by 3.8% year-over-year, from -121.7% to -126.3%.

What is the long-term trend for Zymeworks's net margin?

Over 4 years (2020 to 2025), Zymeworks's net margin has grown at a -36.2% compound annual growth rate (CAGR), from -463.5% to -76.6%.

What does net margin mean?

Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.

Zymeworks ZYME Net margin

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Other financials

Income statement

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Revenue$2.4M-91.1%

Operating income-$47.1M-84.0%

Net income-$44.2M-95.1%

EPS (diluted)-$0.59-96.7%

Balance sheet

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Cash & equivalents$244.3M+221%

Total debt$17.0M-7.7%

Total equity$163.6M-49.7%

Total assets$478.2M+12.4%

Cash flow

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Operating cash flow-$45.7M-1,242%

CapEx$216.0K+1,250%

Free cash flow-$45.9M-1,242%

Valuation

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Market cap$1.76B+125%

Enterprise value$1.53B+112%

P/S21.6×+13.2×

Profitability

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Operating margin-140.4%+7.3pp

FCF margin-94.8%+15.5pp

Returns & leverage

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Return on equity-42%+29.2pp

Debt / equity0.1×0.0×

Current ratio10.8×+6.1×

Where this comes from

Calculated from Zymeworks’s reported figures.

net income/total revenue=-126.3%

Based on trailing twelve months.

The official record: Zymeworks’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Zymeworks's net margin?: Zymeworks (ZYME) reported net margin of -126.3% in Q1 2026.
How has Zymeworks's net margin changed year-over-year?: Zymeworks's net margin decreased by 3.8% year-over-year, from -121.7% to -126.3%.
What is the long-term trend for Zymeworks's net margin?: Over 4 years (2020 to 2025), Zymeworks's net margin has grown at a -36.2% compound annual growth rate (CAGR), from -463.5% to -76.6%.
What does net margin mean?: Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.