What is Amylyx Pharmaceuticals, Inc.'s operating margin?

Amylyx Pharmaceuticals, Inc. (AMLX) reported operating margin of -47,349.8% in Q2 2025.

How has Amylyx Pharmaceuticals, Inc.'s operating margin changed year-over-year?

Amylyx Pharmaceuticals, Inc.'s operating margin decreased by 79480.1% year-over-year, from -59.5% to -47,349.8%.

What does operating margin mean?

Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.

Amylyx Pharmaceuticals, Inc. AMLX Operating margin

Operating margin at other companies

Beam TherapeuticsBEAM

-226.6%-90.5pp

Crinetics PharmaceuticalsCRNX

-3,020.3%-1,463pp

Agios PharmaceuticalsAGIO

-720%-204pp

Rhythm Pharmaceuticals, Inc.RYTM

-90.9%-19.8pp

Taysha Gene Therapies, Inc.TSHA

-1,774.4%+1,437pp

Sarepta Therapeutics, Inc.SRPT

-50.8%-1.6pp

Other financials

Income statement

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Revenue-—

Gross profit-—

Operating income-$43.8M-15.8%

Net income-$41.3M-15.0%

EPS (diluted)-$0.37+11.9%

Balance sheet

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Cash & equivalents$229.1M+283%

Total debt$5.6M+307%

Total equity$273.2M+35.6%

Total assets$293.6M+33.7%

Cash flow

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Operating cash flow-$36.9M+7.4%

CapEx$86.0K+330%

Free cash flow-$28.0M+52.6%

Valuation

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Market cap$1.82B+390%

Enterprise value$1.6B+414%

Profitability

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Gross margin100%+6.9pp

Net margin-45,096.2%-45,152pp

FCF margin-39,826.7%-39,847pp

Returns & leverage

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Return on equity-63.3%-12.2pp

Debt / equity0×0.0×

Current ratio17.9×+5.8×

Where this comes from

Calculated from Amylyx Pharmaceuticals, Inc.’s reported figures.

operating income/total revenue=-47,349.8%

Based on trailing twelve months.

The official record: Amylyx Pharmaceuticals, Inc.’s 10-Q, filed August 7, 2025, on SEC EDGAR. View the filing →

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Questions, answered.

What is Amylyx Pharmaceuticals, Inc.'s operating margin?: Amylyx Pharmaceuticals, Inc. (AMLX) reported operating margin of -47,349.8% in Q2 2025.
How has Amylyx Pharmaceuticals, Inc.'s operating margin changed year-over-year?: Amylyx Pharmaceuticals, Inc.'s operating margin decreased by 79480.1% year-over-year, from -59.5% to -47,349.8%.
What does operating margin mean?: Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.