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Denali Therapeutics Inc. DNLI Q4 2025 Annual earnings

Reported February 26, 2026 · After market close

Revenue-
EPS-$0.73Beat by $0.02
EPS estimate-$0.75

Next report

Aug 6, 2026 (In 1 week)
Revenue estimate$2.2M
EPS estimate-$0.54

Financials

Q4 2025

Income statement

See full
Revenue-—
Operating income-$137.4M-5.8%
Net income-$128.5M-12.0%
EPS (diluted)-$0.73-7.4%

Balance sheet

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Cash & equivalents$208.4M+18.1%
Total debt$42.4M-22.0%
Total equity$1.0B-17.6%
Total assets$1.1B-16.7%

Cash flow

See full
Operating cash flow-$98.5M-17.7%
CapEx$1.5M-70.1%
Free cash flow-$100.1M-12.7%

Valuation & ratios

Valuation

as of 12/31/25
See full
Market cap$2.58B-12.1%
Enterprise value$2.41B-14.2%

Returns & leverage

See full
Return on equity-45.7%+13.0pp
Debt / equity0×0.0×
Current ratio9.2×+0.7×

Segments

By segment

See full
Therapeutics Segment-—

By product

See full
Option Fee Payment$1.3M—

Versus estimates

Diluted EPS

Q1 2026-$0.69Beat by $0.04
Q4 2025-$0.73Beat by $0.02
Q3 2025-$0.74Beat by $0.02Q2 2025-$0.72Beat by $0.02Q1 2025-$0.78Miss by $0.07Q4 2024-$0.67Beat by $0.08

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Questions, answered.

When did Denali Therapeutics Inc. report Q4 2025 earnings?
Denali Therapeutics Inc. (DNLI) reported Q4 2025 earnings on February 26, 2026 after market close.
What were Denali Therapeutics Inc.'s Q4 2025 revenue and EPS?
Denali Therapeutics Inc. reported revenue of - and eps of $-0.73 for Q4 2025.
Did Denali Therapeutics Inc. beat estimates in Q4 2025?
EPS beat the consensus estimate of $-0.75 by $0.02.
How did Denali Therapeutics Inc.'s Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, eps declined 9.0% from $-0.67.
Where can I find Denali Therapeutics Inc.'s Q4 2025 SEC filings?
You can read the 8-K earnings release (0001714899-26-000020) and the 10-K periodic report (0001714899-26-000021) directly on SEC EDGAR. The filing index links above go to sec.gov.