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Denali Therapeutics Inc. DNLI Option Fee Payment — Total collaboration revenue

Other product segments

Milestone Triggered
$25M
Milestone Payment
$2.5M0.0%

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PTH
PTHSLicense and collaboration revenues — Total Revenue
$241K

Other financials

Income statement

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Revenue$3.6M
Gross profit$3.5M
Operating income-$130.5M+3.3%
Net income-$127.6M-2.8%
EPS (diluted)-$0.68+5.6%

Balance sheet

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Cash & equivalents$204.6M+41.8%
Total debt$37.7M-21.4%
Total equity$835.2M-18.7%
Total assets$1.2B-0.7%

Cash flow

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Operating cash flow-$97.0M-28.8%
CapEx$805.0K-81.2%
Free cash flow-$97.8M-22.9%

Valuation

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Market cap$3.92B+88.3%
Enterprise value$3.76B+89.0%
P/S1,089×+1,084×

Profitability

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Operating margin-37,938%-37,986pp
Net margin-33,121.9%-33,159pp
FCF margin-31,736.3%-31,830pp

Returns & leverage

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Return on equity-54.9%+34.3pp
Debt / equity0.0×
Current ratio8.4×-1.9×

Where this comes from

Reported directly by Denali Therapeutics Inc. in its filing.

Tagged under the XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax.

The source filing: Denali Therapeutics Inc.’s 10-Q, filed August 6, 2026.

Filed
Aug 6, 2026, 4:08 PM EDT
Fiscal quarter
Q4 FY2026
Calendar quarter
Q4 2026
Accession
0001714899-26-000097

As of June 30, 2026, the Company had earned an aggregate of $10.0 million in option fee payments and $10.0 million in milestone payments from Takeda under the PTV:PGRN and ATV:TREM2 Collaboration Agreements, and had not recorded any product sales under either agreement.

Item 1. Financial Statements (Unaudited)

FAQ

What is Denali Therapeutics Inc.'s option fee payment — total collaboration revenue?
Denali Therapeutics Inc. (DNLI) reported option fee payment — total collaboration revenue of $2.5M in Q4 2026.
How has Denali Therapeutics Inc.'s option fee payment — total collaboration revenue changed year-over-year?
Denali Therapeutics Inc.'s option fee payment — total collaboration revenue increased by 100.0% year-over-year, from $1.25M to $2.5M.
What is the long-term trend for Denali Therapeutics Inc.'s option fee payment — total collaboration revenue?
Over 3 years (2022 to 2026), Denali Therapeutics Inc.'s option fee payment — total collaboration revenue has grown at a 0.0% compound annual growth rate (CAGR), from $10M to $10M.
What does option fee payment — total collaboration revenue mean?
This metric represents the revenue recognized from option fees associated with collaborative research and development agreements. It reflects the financial value generated when partners exercise rights or pay for the privilege to access the company's proprietary technology platforms or specific therapeutic programs. This revenue stream is a key indicator of the commercial interest in the company's early-stage pipeline and the monetization of its intellectual property through strategic partnerships.

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