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Denali Therapeutics Inc. DNLI Milestone Payment — Total collaboration revenue

Other product segments

Milestone Triggered
$25M
Option Fee Payment
$2.5M+100%

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Other financials

Income statement

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Revenue$3.6M
Gross profit$3.5M
Operating income-$130.5M+3.3%
Net income-$127.6M-2.8%
EPS (diluted)-$0.68+5.6%

Balance sheet

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Cash & equivalents$204.6M+41.8%
Total debt$37.7M-21.4%
Total equity$835.2M-18.7%
Total assets$1.2B-0.7%

Cash flow

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Operating cash flow-$97.0M-28.8%
CapEx$805.0K-81.2%
Free cash flow-$97.8M-22.9%

Valuation

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Market cap$3.92B+88.3%
Enterprise value$3.76B+89.0%
P/S1,089×+1,084×

Profitability

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Operating margin-37,938%-37,986pp
Net margin-33,121.9%-33,159pp
FCF margin-31,736.3%-31,830pp

Returns & leverage

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Return on equity-54.9%+34.3pp
Debt / equity0.0×
Current ratio8.4×-1.9×

Where this comes from

Reported directly by Denali Therapeutics Inc. in its filing.

Tagged under the XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax.

The source filing: Denali Therapeutics Inc.’s 10-Q, filed August 6, 2026.

Filed
Aug 6, 2026, 4:08 PM EDT
Fiscal quarter
Q4 FY2026
Calendar quarter
Q4 2026
Accession
0001714899-26-000097

As of June 30, 2026, the Company had earned an aggregate of $10.0 million in option fee payments and $10.0 million in milestone payments from Takeda under the PTV:PGRN and ATV:TREM2 Collaboration Agreements, and had not recorded any product sales under either agreement.

Item 1. Financial Statements (Unaudited)

FAQ

What is Denali Therapeutics Inc.'s milestone payment — total collaboration revenue?
Denali Therapeutics Inc. (DNLI) reported milestone payment — total collaboration revenue of $2.5M in Q4 2026.
How has Denali Therapeutics Inc.'s milestone payment — total collaboration revenue changed year-over-year?
Denali Therapeutics Inc.'s milestone payment — total collaboration revenue decreased by 0.0% year-over-year, from $2.5M to $2.5M.
What is the long-term trend for Denali Therapeutics Inc.'s milestone payment — total collaboration revenue?
Over 2 years (2024 to 2026), Denali Therapeutics Inc.'s milestone payment — total collaboration revenue has grown at a 0.0% compound annual growth rate (CAGR), from $10M to $10M.
What does milestone payment — total collaboration revenue mean?
This metric represents the total revenue recognized from milestone payments received through strategic research and development collaborations. These payments are typically triggered by the achievement of specific clinical, regulatory, or commercial objectives within a partnership agreement. It serves as a key indicator of the company's ability to successfully advance its pipeline assets and validate its proprietary technology platforms through external validation.

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