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Denali Therapeutics Inc. DNLI Business Segments — Total collaboration revenue

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Other financials

Income statement

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Revenue$3.6M
Gross profit$3.5M
Operating income-$130.5M+3.3%
Net income-$127.6M-2.8%
EPS (diluted)-$0.68+5.6%

Balance sheet

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Cash & equivalents$204.6M+41.8%
Total debt$37.7M-21.4%
Total equity$835.2M-18.7%
Total assets$1.2B-0.7%

Cash flow

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Operating cash flow-$97.0M-28.8%
CapEx$805.0K-81.2%
Free cash flow-$97.8M-22.9%

Valuation

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Market cap$3.92B+88.3%
Enterprise value$3.76B+89.0%
P/S1,089×+1,084×

Profitability

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Operating margin-37,938%-37,986pp
Net margin-33,121.9%-33,159pp
FCF margin-31,736.3%-31,830pp

Returns & leverage

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Return on equity-54.9%+34.3pp
Debt / equity0.0×
Current ratio8.4×-1.9×

Where this comes from

Reported directly by Denali Therapeutics Inc. in its filing.

Tagged under the XBRL concept us-gaap:Revenues.

The source filing: Denali Therapeutics Inc.’s 10-K, filed February 26, 2026.

Filed
Feb 26, 2026, 4:11 PM EST
Fiscal year
FY2025
Accession
0001714899-26-000021
Line itemYear Ended December 31, 2025Year Ended December 31, 2024Year Ended December 31, 2023
Collaboration revenue:
Collaboration revenue from customers(1)$330,531
Total collaboration revenue330,531
Operating expenses:
Research and development(2)418,778396,440423,876
General and administration136,564105,438103,354
Total operating expenses555,342501,878527,230
Gain from divestiture of small molecule programs14,537

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

FAQ

What is Denali Therapeutics Inc.'s business segments — total collaboration revenue?
Denali Therapeutics Inc. (DNLI) reported business segments — total collaboration revenue of $0 in Q4 2025.
What is the long-term trend for Denali Therapeutics Inc.'s business segments — total collaboration revenue?
Over 3 years (2022 to 2025), Denali Therapeutics Inc.'s business segments — total collaboration revenue has grown at a -100.0% compound annual growth rate (CAGR), from $108.46M to $0.
What does business segments — total collaboration revenue mean?
This metric captures the total revenue recognized from strategic partnerships, licensing agreements, and collaborative research arrangements within the therapeutics segment. It reflects the company's ability to monetize its intellectual property and research pipeline through external industry alliances. Fluctuations in this metric often indicate the timing of milestone achievements or the initiation of new joint development programs.

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