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Personalis, Inc. PSNL Operating margin

Operating margin at other companies

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Quest DiagnosticsDGX
14.3%+0.6pp
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NeoGenomicsNEO
-14.2%+1.1pp
Illumina logo
IlluminaILMN
19.4%
Veracyte logo
VeracyteVCYT
14.3%+9.2pp
Guardant Health logo
Guardant HealthGH
-41.4%-9.4pp
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Natera, Inc.NTRA
-13%+0.6pp

Other financials

Income statement

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Revenue$15.5M-24.9%
Gross profit$281.0K-96.1%
Operating income-$32.2M-81.7%
Net income-$30.0M-90.7%
EPS (diluted)-$0.29-61.1%

Balance sheet

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Cash & equivalents$73.6M+3.7%
Total debt$39.0M-6.2%
Total equity$254.8M+22.9%
Total assets$325.4M+19.1%

Cash flow

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Operating cash flow-$22.5M-25.1%
CapEx$3.2M+27.1%
Free cash flow-$25.7M-25.4%

Valuation

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Market cap$1.19B+110%
Enterprise value$1.16B+115%
P/S18.4×+11.8×

Profitability

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Gross margin13.7%-19.6pp
Net margin-148.1%+154pp
FCF margin-131.2%-453pp

Returns & leverage

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Return on equity-41.4%-6.7pp
Debt / equity0.2×0.0×
Current ratio6.6×-0.3×

Where this comes from

Calculated from Personalis, Inc.’s reported figures.

Based on trailing twelve months.

The official record: Personalis, Inc.’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Personalis, Inc.'s operating margin?
Personalis, Inc. (PSNL) reported operating margin of -158.9% in Q1 2026.
How has Personalis, Inc.'s operating margin changed year-over-year?
Personalis, Inc.'s operating margin decreased by 103.0% year-over-year, from -78.3% to -158.9%.
What is the long-term trend for Personalis, Inc.'s operating margin?
Over 5 years (2020 to 2025), Personalis, Inc.'s operating margin has grown at a 18.7% compound annual growth rate (CAGR), from -53.6% to -126.4%.
What does operating margin mean?
Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.