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Other financials

Income statement

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Revenue$213.5M+3,749%
Operating income$158.8M+478%
Net income$162.8M+568%
EPS (diluted)$2.29+516%

Balance sheet

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Cash & equivalents$420.1M+149%
Total debt$9.2M-18.3%
Total equity$841.5M+26.0%
Total assets$885.5M+23.3%

Cash flow

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Operating cash flow$219.1M
CapEx$168.0K-79.3%
Free cash flow$218.9M

Valuation

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Market cap$9.46B+183%
Enterprise value$9.05B+184%
P/E114.1×+49.9×
P/S33.5×+17.6×

Profitability

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Operating margin20.7%+9.2pp
Net margin29.4%+4.5pp
FCF margin-12,264.3%-12,527pp

Returns & leverage

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Return on equity11%+2.4pp
Debt / equity0.0×
Current ratio21.7×+4.7×

Where this comes from

Reported directly by Protagonist Therapeutics in its filing.

Tagged under the XBRL concept us-gaap:PropertyPlantAndEquipmentNet.

The source filing: Protagonist Therapeutics’s 10-K, filed February 25, 2026.

Filed
Feb 25, 2026, 4:28 PM EST
Fiscal year
FY2025
Accession
0001104659-26-019696

Depreciation expense for the years ended December 31, 2025, 2024 and 2023, was $1,225,000, $894,000 and $977,000, respectively. As of December 31, 2025, 2024 and 2023, $40,000, $47,000 and $56,000, respectively, of the Company’s property and equipment, net, was located in Australia. The remainder of the Company’s property and equipment, net was located in the United States.

Item 8. Financial Statements and Supplementary Data

FAQ

What is Protagonist Therapeutics's AU — PP&E (net)?
Protagonist Therapeutics (PTGX) reported AU — PP&E (net) of $40K in Q4 2025.
How has Protagonist Therapeutics's AU — PP&E (net) changed year-over-year?
Protagonist Therapeutics's AU — PP&E (net) decreased by 14.9% year-over-year, from $47K to $40K.
What does AU — PP&E (net) mean?
This metric represents the net book value of tangible assets, such as laboratory equipment, facilities, and infrastructure, located within the Australian geographic segment. It reflects the company's investment in physical capital necessary to support research, development, and operational activities in that region. Monitoring this balance helps investors assess the scale of regional infrastructure and the depreciation profile of assets supporting clinical-stage operations.

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