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Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals Income Statement

Revenue, expenses, and profitability over time

Alnylam Pharmaceuticals generated $4.3B in trailing twelve-month revenue, up 0.8% year-over-year. Net income was $502.3M with a 11.72% net margin. Gross margin stands at 81.0% and operating margin at 17.54%. Diluted EPS is $3.66, which grew 3.0% year-over-year. Based on the Q1 2026 filing.

Total Revenue (TTM)$4.3BGross Profit (TTM)$3.5BOperating Income (TTM)$752.1MNet Income (TTM)$502.3MEps Diluted (TTM)$3.66
Latest FilingQ1 2026
Report Date2026-04-30
Market Cap$38.6B
P/E Ratio76.91
ROE66.91%

Earnings Per Share

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Basic earnings per share$-0.65$-0.14$-0.51$1.91$0.84$1.55
Diluted earnings per share$-0.65$-0.14$-0.51$1.84$0.82$1.51
Weighted-average shares, basic127.7M129.7M130.6M131.4M131M132.9M
Weighted-average shares, diluted127.7M129.7M130.6M137.3M134.7M138.2M

Operating Income

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Gross profit$490.5M$524M$631.7M$1.1B$829.3M$959.7M
Operating income-$105.2M$18.1M-$16.2M$368M$131.7M$268.6M

Income Before Tax

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Income before income taxes-$194M-$2.4M-$35.4M$239M$86.3M$221.7M

Tax

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Income tax expense-$110.2M$15.9M$30.9M-$12.1M—$15.7M

Other Income & Expense

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Interest expense$39M$58.3M$40.2M$44.4M$65.4M$69.3M
Interest income$31M$28.7M$27.5M$28.7M$26.6M$26.6M
Other income (expense), net-$88.8M-$20.4M-$19.2M-$129M-$45.5M-$47M

Net Income

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Net income-$83.8M-$18.3M-$66.3M$251.1M$111.5M$206M

Operating Expenses

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Cost of collaborations and royalties$168K$858K$924K$2.9M$0$3.6M
Research and development$300.2M$265.1M$323.6M$358.8M$372.2M$364.9M
Selling, general and administrative$295.3M$239.9M$323.3M$322.1M$325.4M$322.6M
Total operating expenses$698.3M$576.1M$789.9M$881M$965.3M$898.5M

Other

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Capital investments accrued but not yet paid$1.6M$3.7M$431K$5.5M$1.3M$9.2M
Comprehensive Income (Loss), Net of Tax, Attributable to Parent-$93.5M-$21.3M-$58.7M$259.3M$113.2M$201.2M
Deferred taxes-$107.4M$9.6M$9.7M$5.6M-$27.2M$9.3M
Depreciation, Amortization and Accretion, Net$14.2M$14.4M$13.9M$13.8M$13.5M$13.6M
Income Taxes Paid, Net$6.2M$3M—$1.3M—$2.4M
Increase (Decrease) in Accounts Receivable$59.5M$7.4M$136.9M$399.9M—$110.4M
Increase (decrease) in contract liabilities and current deferred income-$12.8M-$27.3M-$13.1M-$12.5M$0-$1.6M
Increase (Decrease) in Inventories-$849K-$6.2M-$11.1M-$5M—$3.3M
Increase (Decrease) in Prepaid Expense and Other Assets-$25.3M$32.8M$0$20.7M$71M$6.3M
Interest Paid, Excluding Capitalized Interest, Operating Activity$12.3M$68.9M$12.6M$23.9M$113.3M$64.2M
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation$31M$46.1M$51.8M-$448.3M—$15.7M
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation-$52.9M$113.8M-$141.4M$501.1M$0-$25.5M
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation-$94.7M-$120.3M$155.7M$325.1M$163.6M$70.5M
Net unrealized gains (losses) on securities still held-$4.8M$1M-$343K$1.1M$0-$3.7M
Other income, net (Note 6)-$80.8M$9.2M-$6.4M-$74.2M$76.6M-$4.3M
All other operating activities-$6.8M-$19.4M-$18.5M——$3M
Payments to Acquire Debt Securities, Available-for-Sale$486.7M$401.6M$459.6M$208M$235.9M$261.6M
Payments to Acquire Property, Plant, and Equipment$9.1M$9M$14.3M$12.1M$23.3M$21.8M
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options$36.3M$49.4M$81.2M$77.7M$41.7M$13.2M
Revenue From Contract With Customer Excluding Assessed Tax$593.2M$594.2M$773.7M$1.2B$1.1B$1.2B
Stock-based compensation$91.6M$56.7M$111.7M$108.2M$71.6M$70.2M

Cost of Revenue

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Total cost of revenue$102.6M$70.2M$142M$197.2M$267.7M$207.5M

Revenue

MetricQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26
Total revenue$593.2M$594.2M$773.7M$1.2B$1.1B$1.2B