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Alnylam Pharmaceuticals

ALNY

Alnylam Pharmaceuticals is a global commercial-stage biopharmaceutical company that pioneered the development of RNA interference (RNAi) therapeutics.

Market cap
$31.98B-46.3%
Revenue$4.8B+95.1%
Net income$733.1M+362%
Free cash flow$793.9M+1,624%
EPS (diluted)$5.38+348%
Trailing twelve months · change vs. prior year

Earnings

Next report

Oct 29, 2026 (in 2 months)
Revenue estimate$1.4B
EPS estimate$2.19

Financials

Q2 2026

Income statement

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Revenue$1.3B+66.9%
Gross profit$992.7M+57.2%
Operating income$231.4M+1,529%
Net income$164.5M+348%
EPS (diluted)$1.21+337%

Balance sheet

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Cash & equivalents$1.7B+53.2%
Total debt$256.4M-5.2%
Total equity$1.4B+440%
Total assets$5.6B+21.7%

Cash flow

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Operating cash flow$326.7M+113%
CapEx$34.7M+143%
Free cash flow$292.0M+109%

Valuation & ratios

Valuation

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Market cap$31.98B-46.3%
Enterprise value$30.53B-48.0%
P/E43.6×
P/S6.7×-17.5×

Profitability

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Gross margin79.8%-4.1pp
Operating margin20.8%+16.5pp
Net margin15.3%+10.7pp
FCF margin16.5%+14.8pp

Returns & leverage

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Return on equity91.4%
Debt / equity0.2×-0.9×
Current ratio3.1×+0.3×

Segments

By product

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AMVUTTRA$1.0B+106%
GIVLAARI$89.8M+11.0%
OXLUMO$52.1M+11.2%
ONPATTRO$18.5M-64.9%

Competitors

Profile

Alnylam Pharmaceuticals is a global commercial-stage biopharmaceutical company that pioneered the development of RNA interference (RNAi) therapeutics. The company utilizes small interfering RNA (siRNA) to silence specific messenger RNA (mRNA) molecules, preventing the production of disease-causing proteins. Their platform focuses on genetic medicines for rare and prevalent diseases, leveraging proprietary delivery technologies like GalNAc conjugates and lipid nanoparticles.

Competitive position

Alnylam is the industry leader in RNAi therapeutics, holding the first-mover advantage with multiple approved products and a dominant intellectual property position in siRNA delivery.

GeographiesUnited States, European Union, Global
Customer segmentsHealthcare providers, Patients with rare genetic diseases, Global pharmaceutical companies
Business modelR&D-driven drug development, Product licensing, Direct product sales
SuppliersSpecialized chemical suppliers, Contract manufacturing organizations, Genomic research databases
CustomersWholesale drug distributors, Specialty pharmacies, Health insurance providers, Public health systems
Listed2004
Employees2.1K
CEOYvonne L. Greenstreet
FilingsSEC EDGAR

FAQ

What is Alnylam Pharmaceuticals's market cap?
Alnylam Pharmaceuticals (ALNY) has a market capitalization of $32.0B and trades on NASDAQ.
What is Alnylam Pharmaceuticals's revenue and profitability?
Alnylam Pharmaceuticals generated $4.8B in trailing twelve-month revenue with net income of $733.1M, representing a net margin of 15.3%. Gross margin stands at 79.8%, with free cash flow of $793.9M. These figures are based on the Q2 2026 filing.
Who are Alnylam Pharmaceuticals's competitors?
Alnylam Pharmaceuticals's key competitors include Ionis Pharmaceuticals, Arrowhead Pharmaceuticals, Moderna, and others. These companies compete in similar markets and product categories.
Who does Alnylam Pharmaceuticals partner with?
Alnylam Pharmaceuticals's notable partners include Novartis, Sanofi, Regeneron Pharmaceuticals.
Where is Alnylam Pharmaceuticals headquartered?
Alnylam Pharmaceuticals is headquartered in United States of America and employs approximately 2,100 people. It has been publicly traded since 2004.