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Axsome Therapeutics AXSM Q4 2025 Annual earnings

Reported February 23, 2026 · Before market open

Revenue$194.7MBeat by $1.3M
EPS-$0.71Miss by $0.01
Revenue estimate$193.4M
EPS estimate-$0.70

Next report

Nov 2, 2026 (in a month)
Revenue estimate$258.3M
EPS estimate-$0.49

Financials

Q4 2025

Income statement

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Revenue$196.0M+65.0%
Gross profit$183.7M+69.7%
Operating income-$27.0M+62.9%
Net income-$28.6M+61.9%
EPS (diluted)-$0.55+64.3%

Balance sheet

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Cash & equivalents$322.9M+2.4%
Total debt$218.2M+13.1%
Total equity$88.3M+54.9%
Total assets$689.8M+21.3%

Cash flow

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Operating cash flow-$18.7M+28.8%
CapEx$71.0K+137%
Free cash flow-$18.7M+28.6%

Valuation & ratios

Valuation

as of 12/31/25
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Market cap$9.21B+125%
Enterprise value$9.1B+129%
P/S14.4×+3.8×

Profitability

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Gross margin92.6%+1.2pp
Operating margin-26.1%-10.2pp
Net margin-28.7%-10.9pp
FCF margin-14.9%-5.3pp

Returns & leverage

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Return on equity-252.1%+24.5pp
Debt / equity2.5×-0.9×
Current ratio1.6×-0.6×

FAQ

When did Axsome Therapeutics report Q4 2025 earnings?
Axsome Therapeutics (AXSM) reported Q4 2025 earnings on February 23, 2026 before market open.
What were Axsome Therapeutics's Q4 2025 revenue and EPS?
Axsome Therapeutics reported revenue of $194.7M and eps of $-0.71 for Q4 2025.
Did Axsome Therapeutics beat estimates in Q4 2025?
Revenue beat the consensus estimate of $193.4M by $1.3M. EPS missed the consensus estimate of $-0.70 by $0.01.
How did Axsome Therapeutics's Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 63.9% from $118.8M a year earlier and eps grew 26.0% from $-0.96.
Where can I find Axsome Therapeutics's Q4 2025 SEC filings?
You can read the 8-K earnings release (0001193125-26-062421) and the 10-K periodic report (0001193125-26-064267) directly on SEC EDGAR. The filing index links above go to sec.gov.