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Crinetics Pharmaceuticals CRNX Q4 2025 Annual earnings

Reported February 26, 2026 · After market close

Revenue$6.2MBeat by $1.7M
EPS-$1.29Beat by $0.08
Revenue estimate$4.5M
EPS estimate-$1.37

Next report

Aug 4, 2026 (In 6 days)
Revenue estimate$14.8M
EPS estimate-$1.23

Financials

Q4 2025

Income statement

See full
Revenue$6.2M—
Operating income-$133.7M-41.1%
Net income-$122.8M-52.4%
EPS (diluted)-$1.29-48.3%

Balance sheet

See full
Cash & equivalents$102.3M-61.5%
Total debt$48.5M-6.2%
Total equity$992.1M-25.1%
Total assets$1.1B-21.5%

Cash flow

See full
Operating cash flow-$92.9M-38.9%
CapEx$458.0K-55.5%
Free cash flow-$93.4M-37.5%

Valuation & ratios

Valuation

as of 12/31/25
See full
Market cap$4.42B-6.8%
Enterprise value$4.36B-3.6%
P/S574×-3,990×

Profitability

See full
Operating margin-6,714.8%-2,972pp
Net margin-6,046.2%-2,667pp
FCF margin-4,985.5%-2,183pp

Returns & leverage

See full
Return on equity-40.2%+13.7pp
Debt / equity0×0.0×
Current ratio12.3×-10.7×

Segments

By segment

See full
Reportable Segment$6.2M—

Versus estimates

Revenue

Q1 2026$10.7MBeat by $2.2M
Q4 2025$6.2MBeat by $1.7M
Q3 2025$143.0KMiss by $4.2MQ2 2025$1.0MBeat by $637.0KQ1 2025$361.0KBeat by $13.1K

Diluted EPS

Q1 2026-$1.23Miss by $0.01
Q4 2025-$1.29Beat by $0.08
Q3 2025-$1.38Miss by $0.11Q2 2025-$1.23Miss by $0.10Q1 2025-$1.04Miss by $0.05Q4 2024-$0.88Beat by $0.04

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Questions, answered.

When did Crinetics Pharmaceuticals report Q4 2025 earnings?
Crinetics Pharmaceuticals (CRNX) reported Q4 2025 earnings on February 26, 2026 after market close.
What were Crinetics Pharmaceuticals's Q4 2025 revenue and EPS?
Crinetics Pharmaceuticals reported revenue of $6.2M and eps of $-1.29 for Q4 2025.
Did Crinetics Pharmaceuticals beat estimates in Q4 2025?
Revenue beat the consensus estimate of $4.5M by $1.7M. EPS beat the consensus estimate of $-1.37 by $0.08.
How did Crinetics Pharmaceuticals's Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, eps declined 46.6% from $-0.88.
Where can I find Crinetics Pharmaceuticals's Q4 2025 SEC filings?
You can read the 8-K earnings release (0001658247-26-000011) and the 10-K periodic report (0001658247-26-000012) directly on SEC EDGAR. The filing index links above go to sec.gov.