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Denali Therapeutics Inc. DNLI Business Segments — Operating Income (Loss)

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Other financials

Income statement

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Revenue$3.6M
Gross profit$3.5M
Operating income-$130.5M+3.3%
Net income-$127.6M-2.8%
EPS (diluted)-$0.68+5.6%

Balance sheet

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Cash & equivalents$204.6M+41.8%
Total debt$37.7M-21.4%
Total equity$835.2M-18.7%
Total assets$1.2B-0.7%

Cash flow

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Operating cash flow-$97.0M-28.8%
CapEx$805.0K-81.2%
Free cash flow-$97.8M-22.9%

Valuation

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Market cap$3.92B+88.3%
Enterprise value$3.76B+89.0%
P/S1,089×+1,084×

Profitability

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Operating margin-37,938%-37,986pp
Net margin-33,121.9%-33,159pp
FCF margin-31,736.3%-31,830pp

Returns & leverage

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Return on equity-54.9%+34.3pp
Debt / equity0.0×
Current ratio8.4×-1.9×

Where this comes from

Reported directly by Denali Therapeutics Inc. in its filing.

Tagged under the XBRL concept us-gaap:OperatingIncomeLoss.

The source filing: Denali Therapeutics Inc.’s 10-Q, filed August 6, 2026.

Filed
Aug 6, 2026, 4:08 PM EDT
Fiscal quarter
Q4 FY2026
Calendar quarter
Q4 2026
Accession
0001714899-26-000097
Line itemTherapeutics Segment / Three Months Ended June 30, 2026Therapeutics Segment / Three Months Ended June 30, 2025Therapeutics Segment / Six Months Ended June 30, 2026Therapeutics Segment / Six Months Ended June 30, 2025
Personnel related selling, general and administrative expenses22,92120,11545,48538,853
Other selling, general and administrative expenses13,36212,15224,30922,767
Total selling, general and administrative expenses36,28332,26769,79461,620
Intangible asset amortization$750$750
Segment operating expenses134,145134,963271,502280,543
Segment loss from operations(130,541)(134,963)(267,898)(280,543)
Segment interest and other income, net2,98810,84411,89823,454
Segment net loss$(127,553)$(124,119)$(256,000)$(257,089)

Item 1. Financial Statements (Unaudited)

FAQ

What is Denali Therapeutics Inc.'s business segments — operating income (loss)?
Denali Therapeutics Inc. (DNLI) reported business segments — operating income (loss) of -$130.54M in Q2 2026.
How has Denali Therapeutics Inc.'s business segments — operating income (loss) changed year-over-year?
Denali Therapeutics Inc.'s business segments — operating income (loss) increased by 3.3% year-over-year, from -$134.96M to -$130.54M.
What is the long-term trend for Denali Therapeutics Inc.'s business segments — operating income (loss)?
Over 3 years (2022 to 2025), Denali Therapeutics Inc.'s business segments — operating income (loss) has grown at a 17.7% compound annual growth rate (CAGR), from -$340.74M to -$555.34M.
What does business segments — operating income (loss) mean?
Calculated as total segment revenue minus total operating expenses, representing the profitability of the core business operations. For early-stage biotechnology companies, this is typically a loss, reflecting heavy investment in pipeline development. It serves as a primary indicator of the company's progress toward commercial viability.

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