What is Insmed's pre-tax income (domestic)?

Insmed (INSM) reported pre-tax income (domestic) of -$279.62M in Q4 2025.

How has Insmed's pre-tax income (domestic) changed year-over-year?

Insmed's pre-tax income (domestic) decreased by 37.3% year-over-year, from -$203.63M to -$279.62M.

What is the long-term trend for Insmed's pre-tax income (domestic)?

Over 4 years (2021 to 2025), Insmed's pre-tax income (domestic) has grown at a 33.8% compound annual growth rate (CAGR), from -$348.85M to -$1.12B.

What does pre-tax income (domestic) mean?

Pre-tax profit earned specifically from domestic business operations.

Discontinued — last reported Q4 '25

Income Before Tax

Pre-Tax Income (Domestic)

Insmed Pre-Tax Income (Domestic) remained flat by 0.0% to -$279.62M in Q4 2025 compared to the prior quarter. Year-over-year, this metric declined by 37.3%, from -$203.63M to -$279.62M. Over 4 years (FY 2021 to FY 2025), Pre-Tax Income (Domestic) shows a downward trend with a 33.8% CAGR. This decline may warrant attention — for this metric, higher values are generally preferred.

Analysis

StatementIncome Statement

SectionIncome Before Tax

CategoryProfitability

SignalHigher is better

VolatilityStable

First reportedQ1 2015

Last reportedQ4 2025

How to read this metric

An increase suggests strong domestic market demand or operational efficiency within the home region.

Detailed definition

The portion of pre-tax earnings generated from operations within the company's home country. This metric provides insigh...

Peer comparison

Standard geographic breakdown provided by most multinational corporations.

Metric ID: msft_income_before_tax_domestic

Historical Data

5 years

	FY'21	FY'22	FY'23	FY'24	FY'25
Value	-$348.85M	-$406.26M	-$666.18M	-$814.53M	-$1.12B
YoY Change	—	-16.5%	-64.0%	-22.3%	-37.3%

Range-$1.12B – -$348.85M

CAGR+33.8%

Avg YoY Growth-35.0%

Median YoY Growth-29.8%

Current Streak4+ years decline

Pre-Tax Income (Domestic) at Other Companies

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Frequently Asked Questions

What is Insmed's pre-tax income (domestic)?: Insmed (INSM) reported pre-tax income (domestic) of -$279.62M in Q4 2025.
How has Insmed's pre-tax income (domestic) changed year-over-year?: Insmed's pre-tax income (domestic) decreased by 37.3% year-over-year, from -$203.63M to -$279.62M.
What is the long-term trend for Insmed's pre-tax income (domestic)?: Over 4 years (2021 to 2025), Insmed's pre-tax income (domestic) has grown at a 33.8% compound annual growth rate (CAGR), from -$348.85M to -$1.12B.
What does pre-tax income (domestic) mean?: Pre-tax profit earned specifically from domestic business operations.