| Revenue | $2.6B | $2.8B | $2.9B | $2.8B | $3.0B | $3.1B | $3.2B | $3.0B |
| Payments to Acquire Debt Securities, Available-for-Sale | $1.3B | $1.4B | $2.2B | $1.6B | $2.2B | $1.3B | $1.2B | $2.5B |
| Proceeds from sales and redemptions of investments in debt securities classified as available for sale | $1.2B | $1.1B | $1.5B | $1.6B | $1.8B | $1.3B | $1.1B | $2.2B |
| Cash Provided by (Used in) Operating Activity, Including Discontinued Operation | -$123.2M | -$123.2M | -$123.2M | $818.9M | $1.1B | $1.2B | $498.0M | $1.4B |
| Research and development expense | $966.6M | $875.9M | $998.7M | $979.7M | $978.4M | $977.7M | $973.7M | $961.6M |
| Cash Provided by (Used in) Financing Activity, Including Discontinued Operation | -$358.6M | -$387.5M | -$391.3M | -$680.4M | -$349.2M | -$1.2B | -$77.2M | -$538.8M |
| Cash Provided by (Used in) Investing Activity, Including Discontinued Operation | -$463.7M | -$348.0M | -$821.9M | -$55.8M | -$484.5M | -$117.0M | -$288.1M | -$431.9M |
| Payments for Repurchase of Common Stock | $320.3M | $307.7M | $417.9M | $426.1M | $391.8M | $1.1B | $128.4M | $336.9M |
| Tax Withholding for Share-Based Payments | $80.5M | $83.7M | $7.3M | $270.5M | $5.9M | $91.0M | $2.5M | $228.5M |
| Payment, Tax Withholding, Share-Based Payment Arrangement | $80.5M | $83.7M | $7.3M | $270.5M | $5.9M | $91.0M | $2.5M | $228.5M |
| Increase (Decrease) in Prepaid Expense and Other Assets | $155.9M | — | $164.6M | $28.1M | $76.4M | $40.9M | $250.6M | -$173.4M |
| Stock-based compensation | $154.2M | $184.6M | $167.8M | $166.1M | $167.3M | $194.9M | $157.6M | $166.4M |
| Capital Expenditures | $69.0M | $67.7M | $92.6M | $40.7M | $145.7M | $101.8M | $149.4M | $133.4M |
| Payments to Acquire Property, Plant, and Equipment | $69.0M | $67.7M | $92.6M | $40.7M | $145.7M | $101.8M | $149.4M | $133.4M |
| Net interest and investment income (loss) | — | — | — | $117.9M | — | — | — | $114.8M |
| Increase (Decrease) in Inventories | $107.2M | $182.5M | $147.5M | $167.1M | $148.6M | $131.1M | $77.4M | $97.7M |
| Income Taxes Paid, Net | $497.0M | $278.5M | $271.8M | $184.4M | $513.3M | $479.6M | $389.4M | $82.3M |
| Income Taxes Paid, Net | $497.0M | $278.5M | $271.8M | $184.4M | $513.3M | $479.6M | $389.4M | $82.3M |
| Increase in accrued expenses and other liabilities | $168.3M | $170.6M | — | $48.1M | $166.6M | $332.9M | -$664.5M | $70.5M |
| Change in Accounts Receivable | — | $51.8M | — | $169.6M | $18.4M | $59.9M | $99.4M | -$39.8M |
| Increase (Decrease) in Accounts Receivable | — | $51.8M | — | $169.6M | $18.4M | $59.9M | $99.4M | -$39.8M |
| Accounts payable | -$25.1M | $66.1M | $8.4M | $26.2M | $7.6M | -$35.3M | $38.3M | $35.6M |
| Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options | $55.0M | $8.4M | $34.3M | $16.7M | $49.1M | $7.9M | $54.0M | $27.0M |
| Change in Other Liabilities | -$256.6M | $134.1M | — | $22.0M | -$63.2M | $83.9M | $105.8M | $23.1M |
| Other liabilities | -$256.6M | $134.1M | — | $22.0M | -$63.2M | $83.9M | $105.8M | $23.1M |
| Other Noncash Income (Expense) | $20.7M | -$41.6M | -$16.4M | -$39.2M | -$57.8M | $0.0 | -$23.1M | $5.0M |
| Interest Paid, Net | $9.7M | $8.1M | $2.7M | $2.7M | $3.5M | $3.2M | $3.0M | $3.2M |
| Interest Paid, Excluding Capitalized Interest, Operating Activity | $9.7M | $8.1M | $2.7M | $2.7M | $3.5M | $3.2M | $3.0M | $3.2M |
| Financing — other | $900.0K | $900.0K | $900.0K | -$500.0K | $2.0M | $1.1M | $1.1M | -$400.0K |
| Advertising costs | $21.4M | $21.4M | $21.4M | $50.7M | $50.7M | $50.7M | $50.7M | — |
| Amortization of capitalized software and acquired intangible assets | $5.1M | $5.1M | $5.1M | $5.1M | $5.1M | $5.1M | $5.1M | — |
| Software amortization expense | $6.3M | $6.3M | $6.3M | $7.8M | $7.8M | $7.8M | $7.8M | — |
| Common stock, number of votes per share | — | — | — | $0.3 | $0.3 | $0.3 | $0.3 | — |
| Federal | $176.2M | $176.2M | $176.2M | $169.8M | $169.8M | $169.8M | $169.8M | — |
| Foreign | $77.5M | $77.5M | $77.5M | $121.5M | $121.5M | $121.5M | $121.5M | — |
| Federal | -$109.7M | -$109.7M | -$109.7M | -$131.8M | -$131.8M | -$131.8M | -$131.8M | — |
| Deferred taxes | -$87.2M | -$87.2M | -$87.2M | -$127.7M | -$127.7M | -$127.7M | -$127.7M | — |
| State | -$12.2M | -$12.2M | -$12.2M | -$5.5M | -$5.5M | -$5.5M | -$5.5M | — |
| Maximum percentage of annual compensation contributed by the participant (percent) | — | — | — | — | — | — | 60.0% | — |
| Depreciation | $40.1M | $40.1M | $40.1M | $39.0M | $39.0M | $39.0M | $39.0M | — |
| Income taxes at U.S. statutory rate of 21% | $0.1 | $0.1 | $0.1 | $0.1 | $0.1 | $0.1 | $0.1 | — |
| Effective Income Tax Rate Reconciliation, Cross-Border, Other, Amount | — | — | — | $200.0K | $200.0K | $200.0K | $200.0K | — |
| Subpart F income, net of credits | — | — | — | — | — | — | -2.1% | — |
| Subpart F income, net of credits | — | — | — | -$24.4M | -$24.4M | -$24.4M | -$24.4M | — |
| Other | — | — | — | — | — | — | 0.0% | — |
| Deferred charges related to intra-entity transfers | — | — | — | -$15.4M | -$15.4M | -$15.4M | -$15.4M | — |
| Deferred charges related to intra-entity transfers | — | — | — | — | — | — | -1.3% | — |
| Effective Income Tax Rate Reconciliation, FDII, Amount | — | — | — | $14.6M | $14.6M | $14.6M | $14.6M | — |
| Effective Income Tax Rate Reconciliation, FDII, Percent | — | — | 28.3% | — | — | — | 1.3% | — |
| Foreign operations | $0.1 | $0.1 | $0.1 | — | — | — | — | — |
| Non-deductible AIPR&D | — | — | 373.8% | — | — | — | — | — |
| Other | — | — | — | $0.0 | $0.0 | $0.0 | $0.0 | — |
| U.S. tax on foreign earnings, net of credits | — | — | -12.6% | — | — | — | — | — |
| State income taxes – net of federal income tax benefit | $0.1 | $0.1 | $0.1 | $0.0 | $0.0 | $0.0 | $0.0 | — |
| Changes in unrecognized tax benefits | — | — | 11.3% | — | — | — | 1.4% | — |
| Gain (Loss), Foreign Currency Transaction, before Tax | -$6.8M | -$6.8M | -$6.8M | -$3.4M | -$3.4M | -$3.4M | -$3.4M | — |
| Federal taxes | — | — | — | $242.2M | $242.2M | $242.2M | $242.2M | — |
| State taxes | — | — | — | $18.6M | $18.6M | $18.6M | $18.6M | — |
| Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount | — | — | — | $243.8M | $243.8M | $243.8M | $243.8M | — |
| Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount | — | — | — | $6.4M | $6.4M | $6.4M | $6.4M | — |
| Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount | — | — | — | -$475.0K | -$475.0K | -$475.0K | -$475.0K | — |
| Changes in unrecognized tax benefits | — | — | — | $16.1M | $16.1M | $16.1M | $16.1M | — |
| Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount | — | — | — | $38.6M | $38.6M | $38.6M | $38.6M | — |
| Effective Income Tax Rate Reconciliation, Tax Exempt Income, Amount | — | — | — | $15.5M | $15.5M | $15.5M | $15.5M | — |
| Net payments due to CRISPR Therapeutics AG related to finite-lived intangible assets | $0.0 | $0.0 | $0.0 | $0.0 | $0.0 | $0.0 | $0.0 | — |
| Operating Lease Payments | $28.4M | $28.4M | $28.4M | $45.8M | $45.8M | $45.8M | $45.8M | — |
| Other income, net (Note 6) | -$23.1M | -$16.9M | -$14.9M | -$17.6M | $13.2M | -$9.8M | — | $0.0 |
| Payment for (Proceeds from) Other Investing Activity | $15.0M | $8.1M | $30.9M | $5.3M | $4.3M | $0.0 | $15.9M | $0.0 |
| Cash received from option exercises | $12.5M | $12.5M | $12.5M | $13.9M | $13.9M | $13.9M | $13.9M | — |
| Property, Plant and Equipment, Gross, Period Increase (Decrease) | — | — | — | -$26.9M | -$26.9M | -$26.9M | -$26.9M | — |
| Reduction to finance leases | — | — | — | $68.8M | $68.8M | $68.8M | $68.8M | — |
| Granted (in shares) | — | — | — | — | — | — | 7K | — |
| Intrinsic value of stock options exercised | $28.2M | $28.2M | $28.2M | $37.0M | $37.0M | $37.0M | $37.0M | — |
| Granted (in shares) | — | — | — | — | — | — | $502.97 | — |
| Exercised (in shares) | — | — | — | — | — | — | $125.30 | — |
| Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period | — | — | — | — | — | — | 447K | — |
| Stock Repurchased During Period Shares | $675.0K | $675.0K | $675.0K | $1.2M | $1.2M | $1.2M | $1.2M | — |
| Unrecognized tax benefits, settlements | $3.6M | $3.6M | $3.6M | $1.6M | $1.6M | $1.6M | $1.6M | — |
| Unrecognized Tax Benefits, Decrease Resulting from Foreign Currency Translation | $125.0K | $125.0K | $125.0K | — | — | — | — | — |
| Unrecognized tax benefits, deferred tax liabilities, gross | $23.0M | $23.0M | $23.0M | $34.6M | $34.6M | $34.6M | $34.6M | — |
| Interest expense and penalties, net (benefit)/charge recognized | -$10.4M | -$10.4M | -$10.4M | $3.3M | $3.3M | $3.3M | $3.3M | — |
| Unrecognized tax benefits, increase (decrease) in deferred tax assets, gross | $400.0K | $400.0K | $400.0K | -$1.9M | -$1.9M | -$1.9M | -$1.9M | — |
| Foreign currency effect | — | — | — | $11.0M | $11.0M | $11.0M | $11.0M | — |
| Additions for tax positions of prior years | $1.2M | $1.2M | $1.2M | $1.3M | $1.3M | $1.3M | $1.3M | — |
| Increase (decrease) in amount of unrecognized tax benefits | $22.6M | $22.6M | $22.6M | $36.5M | $36.5M | $36.5M | $36.5M | — |
