What are Agios Pharmaceuticals's profit margins?

Agios Pharmaceuticals (AGIO) runs a 90.0% gross margin and a -720.0% operating margin, with a -639.8% net margin.

Where do Agios Pharmaceuticals's ratios come from?

Every ratio is computed from Agios Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Agios Pharmaceuticals AGIO Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	90%+2.5pp	88.3%-0.3pp	87.2%-2.2pp	88.2%-1.1pp	87.5%-2.4pp
Operating margin	-720%+469pp	-873.9%+293pp	-1,061.8%+176pp	-1,129.1%+165pp	-1,188.9%+148pp
Net margin	-639.8%—	-764%—	——	——	——
Returns
Return on equity	-32.8%—	-30.2%—	——	——	——
Return on invested capital	-38.5%+2.8pp	-35.4%+1.3pp	-35.6%-0.7pp	-46.7%+4.0pp	-41.3%+4.7pp
Efficiency
Asset turnover	0×0.0×	0×0.0×	0×0.0×	0×0.0×	0×0.0×
Liquidity
Current ratio	14.2×-4.3×	11.5×-0.4×	13.8×+4.8×	14.5×+4.4×	18.5×+5.7×
Leverage
Debt-to-equity	0×0.0×	0×0.0×	0×0.0×	0×-0.1×	0×-0.1×
Per Share
Book value per share	$18.87-26.1%	$20.58-22.7%	$22.09-20.6%	$23.64+103%	$25.52+93.4%
Valuation
Market capitalization	$1.98B+18.1%	$1.59B-15.3%	$2.33B-7.7%	$1.94B-20.9%	$1.68B+2.2%
Price / sales	30×-15.3×	29.4×-22.0×	52.1×-24.8×	47.4×-30.8×	45.3×-10.6×
Price / book	1.8×+0.6×	1.3×+0.1×	1.8×+0.3×	1.4×-2.3×	1.1×-1.1×

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Questions, answered.

What are Agios Pharmaceuticals's profit margins?: Agios Pharmaceuticals (AGIO) runs a 90.0% gross margin and a -720.0% operating margin, with a -639.8% net margin.
Where do Agios Pharmaceuticals's ratios come from?: Every ratio is computed from Agios Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.