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Denali Therapeutics Inc. DNLI Business Segments — Operating Expenses

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Other financials

Income statement

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Revenue$3.6M
Gross profit$3.5M
Operating income-$130.5M+3.3%
Net income-$127.6M-2.8%
EPS (diluted)-$0.68+5.6%

Balance sheet

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Cash & equivalents$204.6M+41.8%
Total debt$37.7M-21.4%
Total equity$835.2M-18.7%
Total assets$1.2B-0.7%

Cash flow

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Operating cash flow-$97.0M-28.8%
CapEx$805.0K-81.2%
Free cash flow-$97.8M-22.9%

Valuation

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Market cap$3.92B+88.3%
Enterprise value$3.76B+89.0%
P/S1,089×+1,084×

Profitability

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Operating margin-37,938%-37,986pp
Net margin-33,121.9%-33,159pp
FCF margin-31,736.3%-31,830pp

Returns & leverage

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Return on equity-54.9%+34.3pp
Debt / equity0.0×
Current ratio8.4×-1.9×

Where this comes from

Reported directly by Denali Therapeutics Inc. in its filing.

Tagged under the XBRL concept us-gaap:CostsAndExpenses.

The source filing: Denali Therapeutics Inc.’s 10-Q, filed August 6, 2026.

Filed
Aug 6, 2026, 4:08 PM EDT
Fiscal quarter
Q4 FY2026
Calendar quarter
Q4 2026
Accession
0001714899-26-000097
Line itemTherapeutics Segment / Three Months Ended June 30, 2026Therapeutics Segment / Three Months Ended June 30, 2025Therapeutics Segment / Six Months Ended June 30, 2026Therapeutics Segment / Six Months Ended June 30, 2025
Personnel related selling, general and administrative expenses22,92120,11545,48538,853
Other selling, general and administrative expenses13,36212,15224,30922,767
Total selling, general and administrative expenses36,28332,26769,79461,620
Intangible asset amortization$750$750
Segment operating expenses134,145134,963271,502280,543
Segment loss from operations(130,541)(134,963)(267,898)(280,543)
Segment interest and other income, net2,98810,84411,89823,454
Segment net loss$(127,553)$(124,119)$(256,000)$(257,089)

Item 1. Financial Statements (Unaudited)

FAQ

What is Denali Therapeutics Inc.'s business segments — operating expenses?
Denali Therapeutics Inc. (DNLI) reported business segments — operating expenses of $134.15M in Q2 2026.
How has Denali Therapeutics Inc.'s business segments — operating expenses changed year-over-year?
Denali Therapeutics Inc.'s business segments — operating expenses decreased by 0.6% year-over-year, from $134.96M to $134.15M.
What is the long-term trend for Denali Therapeutics Inc.'s business segments — operating expenses?
Over 3 years (2022 to 2025), Denali Therapeutics Inc.'s business segments — operating expenses has grown at a 7.3% compound annual growth rate (CAGR), from $449.21M to $555.34M.
What does business segments — operating expenses mean?
The sum of all research, development, and administrative costs incurred during the period. This metric represents the total cash outflow required to sustain the company's operations before accounting for revenue or financing activities. It is a critical measure for evaluating the company's overall operational scale and cash burn.

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