Where do Prime Medicine's ratios come from?

Every ratio is computed from Prime Medicine's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Prime Medicine PRME Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Returns
Return on equity	-216.1%-101pp	-146.8%-9.9pp	-112.3%+2.0pp	-154.8%-55.2pp	-115.2%-36.9pp
Return on invested capital	-175.4%-38.7pp	——	-138.9%+40.5pp	-144.7%+15.8pp	-136.8%-10.5pp
Liquidity
Current ratio	3.8×-1.0×	4.8×-0.7×	6.6×+0.1×	3.6×-4.7×	4.8×-4.1×
Leverage
Debt-to-equity	1.5×+0.4×	1×+0.7×	0.7×+0.5×	2×+1.8×	1.1×+1.0×
Per Share
Book value per share	$0.43-47.0%	$0.81-37.1%	$1.01-36.3%	$0.47-71.4%	$0.82-65.0%
Valuation
Market capitalization	$574.36M+111%	$626.37M+63.5%	$987.64M+114%	$283.6M-53.7%	$261.01M-64.3%
Price / book	7.5×+4.9×	5.2×+2.7×	6.1×+3.7×	4.7×+1.5×	2.4×-0.6×

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Where do Prime Medicine's ratios come from?: Every ratio is computed from Prime Medicine's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.