What is Prime Medicine's return on invested capital?

Prime Medicine (PRME) reported return on invested capital of -175.4% in Q1 2026.

How has Prime Medicine's return on invested capital changed year-over-year?

Prime Medicine's return on invested capital decreased by 28.3% year-over-year, from -136.8% to -175.4%.

What does return on invested capital mean?

Net operating profit after tax (operating income taxed at the effective rate) divided by average invested capital (debt plus equity minus cash). Measures the after-tax return on all capital put to work in the business, independent of capital structure.

Prime Medicine PRME Return on invested capital

Return on invested capital at other companies

Eli LillyLLY

42%+16.6pp

Vertex PharmaceuticalsVRTX

26.8%+23.0pp

Intellia TherapeuticsNTLA

-62.8%+0.9pp

CRISPR TherapeuticsCRSP

-32.4%+6.6pp

Beam TherapeuticsBEAM

-39.4%-8.8pp

RegenxbioRGNX

-170.6%-314pp

Other financials

Income statement

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Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

FCF margin-3,607.4%—

Returns & leverage

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Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

nopat/invested capital=-175.4%

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's return on invested capital?: Prime Medicine (PRME) reported return on invested capital of -175.4% in Q1 2026.
How has Prime Medicine's return on invested capital changed year-over-year?: Prime Medicine's return on invested capital decreased by 28.3% year-over-year, from -136.8% to -175.4%.
What does return on invested capital mean?: Net operating profit after tax (operating income taxed at the effective rate) divided by average invested capital (debt plus equity minus cash). Measures the after-tax return on all capital put to work in the business, independent of capital structure.