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Prime Medicine PRME Operating margin

Operating margin at other companies

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-636.6%-202pp
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-15,754.2%-17,253pp
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Other financials

Income statement

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Revenue$838.0K-61.6%
Operating income-$50.7M+3.3%
Net income-$49.1M+5.3%
EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%
Total debt$114.5M-5.5%
Total equity$76.7M-28.3%
Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%
CapEx$214.0K-91.2%
Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%
Enterprise value$611.08M+113%
P/S124×+6.3×

Profitability

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Net margin-4,342.4%-1,099pp
FCF margin-3,607.4%

Returns & leverage

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Return on equity-216.1%+1,519pp
Debt / equity1.5×+0.4×
Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's operating margin?
Prime Medicine (PRME) reported operating margin of -4,498.1% in Q4 2025.
How has Prime Medicine's operating margin changed year-over-year?
Prime Medicine's operating margin increased by 33.7% year-over-year, from -6,787.4% to -4,498.1%.
What is the long-term trend for Prime Medicine's operating margin?
Over 2 years (2020 to 2025), Prime Medicine's operating margin has grown at a 1485.7% compound annual growth rate (CAGR), from -17.9% to -4,498.1%.
What does operating margin mean?
Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.