What is Prime Medicine's net margin?

Prime Medicine (PRME) reported net margin of -4,342.4% in Q4 2025.

How has Prime Medicine's net margin changed year-over-year?

Prime Medicine's net margin increased by 33.9% year-over-year, from -6,566.6% to -4,342.4%.

What is the long-term trend for Prime Medicine's net margin?

Over 2 years (2020 to 2025), Prime Medicine's net margin has grown at a 714.5% compound annual growth rate (CAGR), from -65.5% to -4,342.4%.

What does net margin mean?

Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.

Prime Medicine PRME Net margin

Net margin at other companies

Eli LillyLLY

35%+12.3pp

Vertex PharmaceuticalsVRTX

35.5%—

Intellia TherapeuticsNTLA

-597%-194pp

CRISPR TherapeuticsCRSP

-13,856.5%-15,058pp

Beam TherapeuticsBEAM

-742.7%—

RegenxbioRGNX

-330.2%-588pp

Other financials

Income statement

See full

Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

See full

Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

See full

Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

See full

Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

See full

Operating margin-4,498.1%-1,134pp

FCF margin-3,607.4%—

Returns & leverage

See full

Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

net income/total revenue=-4,342.4%

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

Ask your AI about Prime Medicine's net margin.

Connect your AI assistant and compare it to peers, right in your chat.

Connect your AI

Claude

Questions, answered.

What is Prime Medicine's net margin?: Prime Medicine (PRME) reported net margin of -4,342.4% in Q4 2025.
How has Prime Medicine's net margin changed year-over-year?: Prime Medicine's net margin increased by 33.9% year-over-year, from -6,566.6% to -4,342.4%.
What is the long-term trend for Prime Medicine's net margin?: Over 2 years (2020 to 2025), Prime Medicine's net margin has grown at a 714.5% compound annual growth rate (CAGR), from -65.5% to -4,342.4%.
What does net margin mean?: Net income as a percentage of revenue (trailing twelve months). The bottom-line profitability measure after all costs, interest, and taxes.