What is Prime Medicine's free cash flow margin?

Prime Medicine (PRME) reported free cash flow margin of -3,607.4% in Q4 2025.

What does free cash flow margin mean?

Free cash flow (operating cash flow minus capital expenditures) as a percentage of revenue, trailing twelve months. Measures how efficiently revenue converts into discretionary cash.

Prime Medicine PRME Free cash flow margin

Free cash flow margin at other companies

Eli LillyLLY

16.4%+8.7pp

Vertex PharmaceuticalsVRTX

30.4%+20.2pp

Intellia TherapeuticsNTLA

-550.2%-140pp

CRISPR TherapeuticsCRSP

-9,777.6%-10,759pp

Beam TherapeuticsBEAM

-234%-86.6pp

RegenxbioRGNX

-269.2%-364pp

Other financials

Income statement

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Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

Returns & leverage

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Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

free cash flow/total revenue=-3,607.4%

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's free cash flow margin?: Prime Medicine (PRME) reported free cash flow margin of -3,607.4% in Q4 2025.
What does free cash flow margin mean?: Free cash flow (operating cash flow minus capital expenditures) as a percentage of revenue, trailing twelve months. Measures how efficiently revenue converts into discretionary cash.