What is Prime Medicine's total revenue?

Prime Medicine (PRME) reported total revenue of $838K in Q4 2025.

How has Prime Medicine's total revenue changed year-over-year?

Prime Medicine's total revenue decreased by 61.6% year-over-year, from $2.18M to $838K.

What does total revenue mean?

The aggregate of all revenue from the company's operations — the top line from which all profitability metrics are derived.

Prime Medicine PRME Total Revenue

Total Revenue at other companies

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$19.8B+55.5%

Vertex PharmaceuticalsVRTX

$2.99B+7.8%

Intellia TherapeuticsNTLA

$15.05M-9.5%

CRISPR TherapeuticsCRSP

$1.46M+68.6%

Beam TherapeuticsBEAM

$31.74M+325%

RegenxbioRGNX

$6.39M-92.8%

Segments

By segment

See full

Reportable Segment$856K-41.1%

Other financials

Income statement

See full

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

See full

Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

See full

Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

See full

Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

See full

Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

FCF margin-3,607.4%—

Returns & leverage

See full

Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Reported directly by Prime Medicine in its filing.

Tagged under the XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax.

The official record: Prime Medicine’s 10-K, filed March 3, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's total revenue?: Prime Medicine (PRME) reported total revenue of $838K in Q4 2025.
How has Prime Medicine's total revenue changed year-over-year?: Prime Medicine's total revenue decreased by 61.6% year-over-year, from $2.18M to $838K.
What does total revenue mean?: The aggregate of all revenue from the company's operations — the top line from which all profitability metrics are derived.