What are Vertex Pharmaceuticals's profit margins?

Vertex Pharmaceuticals (VRTX) runs a 86.2% gross margin and a 38.3% operating margin, with a 35.5% net margin.

Where do Vertex Pharmaceuticals's ratios come from?

Every ratio is computed from Vertex Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Vertex Pharmaceuticals VRTX Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	TTM Q1 '26	TTM Q4 '25	TTM Q3 '25	TTM Q2 '25	TTM Q1 '25
Profitability
Gross margin	344.9%+0.2pp	344.7%-0.9pp	344.5%-2.1pp	344.4%-4.0pp	344.7%-5.1pp
EBITDA margin	150.5%+155pp	106.5%+64.5pp	70.8%-11.1pp	33.6%-90.6pp	-4.9%-174pp
Free cash flow margin	91%+185pp	29.7%+56.2pp	-24%-58.3pp	-71.1%-174pp	-94%-249pp
Returns
Return on invested capital	103.9%+112pp	71.8%+44.5pp	46.9%-13.0pp	20%-69.2pp	-8.5%-128pp
Efficiency
Asset turnover	2×+0.1×	2×0.0×	2×0.0×	2×0.0×	2×0.0×
Inventory turnover	4.7×-1.8×	5.1×-2.0×	5.5×-2.1×	6×-2.1×	6.5×-2.1×
Liquidity
Current ratio	10.8×+0.5×	10.4×-0.8×	10.2×-2.3×	10.3×-3.8×	10.3×-5.4×
Quick ratio	9.2×+0.1×	8.9×-1.2×	8.8×-2.7×	9×-4.2×	9.1×-5.8×
Cash ratio	5×-0.1×	4.9×-1.4×	4.8×-3.1×	5×-3.1×	5.1×-3.0×
Leverage
Debt-to-equity	0.4×0.0×	0.4×+0.1×	0.4×+0.1×	0.4×+0.2×	0.4×+0.2×
Debt-to-assets	0.3×0.0×	0.3×+0.1×	0.3×+0.1×	0.3×+0.1×	0.3×+0.1×
Net debt / EBITDA	-3×—	——	——	——	——
Per Share
Book value per share	$281.46+15.2%	$269.49+7.0%	$260.77+2.0%	$253.43-2.2%	$244.33-6.5%
Valuation
Market capitalization	$444.5B-5.3%	$455.56B+0.6%	$444.24B-2.1%	$463.87B+9.5%	$469.26B+19.3%
Enterprise value	$431.37B-5.5%	$442.91B+2.0%	$431.82B+0.7%	$451.09B+13.6%	$456.28B+24.3%
Price / sales	37.6×-6.1×	39.5×-3.5×	39.3×-4.9×	42×-0.2×	43.6×+3.6×
Price / book	24.6×-5.2×	26.2×-1.8×	26.4×-1.3×	28.3×+2.9×	29.7×+6.7×
EV / EBITDA	97.1×—	——	——	——	——
EV / sales	36.4×-6.0×	38.4×-2.8×	38.2×-3.5×	40.9×+1.3×	42.4×+5.0×
Free cash flow yield	9.8%+18.6pp	3.8%+6.4pp	-1.9%-5.3pp	-6.7%-17.0pp	-8.8%-24.4pp

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Questions, answered.

What are Vertex Pharmaceuticals's profit margins?: Vertex Pharmaceuticals (VRTX) runs a 86.2% gross margin and a 38.3% operating margin, with a 35.5% net margin.
Where do Vertex Pharmaceuticals's ratios come from?: Every ratio is computed from Vertex Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.