What are Vertex Pharmaceuticals's profit margins?

Vertex Pharmaceuticals (VRTX) runs a 86.2% gross margin and a 38.3% operating margin, with a 35.5% net margin.

Where do Vertex Pharmaceuticals's ratios come from?

Every ratio is computed from Vertex Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Vertex Pharmaceuticals VRTX Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	86.2%+0.2pp	86.2%+0.1pp	86.3%+0.2pp	86.1%-0.3pp	86%-0.8pp
Operating margin	38.3%—	34.8%—	——	——	——
Net margin	35.5%—	32.9%—	——	——	——
EBITDA margin	40.1%+43.9pp	36.5%+35.7pp	36.7%+37.2pp	37.1%+38.5pp	-3.8%-46.9pp
Free cash flow margin	30.4%+61.4pp	26.6%+53.6pp	22.6%+47.1pp	11.5%+22.9pp	-31%-67.5pp
Returns
Return on equity	24.2%—	22.5%—	——	——	——
Return on assets	17.6%—	16.4%—	——	——	——
Return on invested capital	26.8%+32.2pp	24.3%+24.9pp	25.7%+26.9pp	27%+28.5pp	-5.3%-35.8pp
Efficiency
Asset turnover	0.5×0.0×	0.5×0.0×	0.5×0.0×	0.5×0.0×	0.5×0.0×
Inventory turnover	1.1×-0.4×	1.1×-0.4×	1.2×-0.5×	1.3×-0.5×	1.4×-0.6×
Liquidity
Current ratio	3×+0.4×	2.9×+0.2×	2.4×-0.1×	2.5×0.0×	2.6×-0.9×
Quick ratio	2.6×+0.3×	2.5×+0.1×	2×-0.2×	2.2×-0.1×	2.3×-1.0×
Cash ratio	1.4×+0.2×	1.3×0.0×	1.1×-0.2×	1.2×-0.1×	1.2×-1.2×
Leverage
Debt-to-equity	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×+0.1×
Debt-to-assets	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Net debt / EBITDA	-0.7×—	-0.7×+31.5×	-0.7×—	-0.8×—	——
Per Share
Book value per share	$75.54+18.8%	$72.35+13.7%	$67.23+12.3%	$66.34+15.9%	$63.57-10.5%
Valuation
Market capitalization	$113.44B-8.9%	$115.03B+10.9%	$100.41B-16.3%	$115.63B-4.5%	$124.5B+15.3%
Enterprise value	$109.92B-9.5%	$111.97B+11.0%	$97.3B-16.5%	$112.17B-4.4%	$121.46B+22.1%
Price / earnings	26.1×—	29.1×—	——	——	——
Price / sales	9.3×-1.9×	9.6×+0.2×	8.6×-2.7×	10.1×-1.6×	11.2×+0.6×
Price / book	5.9×-1.7×	6.2×-0.2×	5.8×-1.9×	6.7×-1.5×	7.5×+1.7×
EV / EBITDA	22.4×—	25.5×-1,126×	22.6×—	26.5×—	——
EV / sales	9×-1.9×	9.3×+0.2×	8.3×-2.7×	9.8×-1.5×	10.9×+1.2×
Free cash flow yield	3.3%+6.0pp	2.8%+5.6pp	2.6%+4.8pp	1.1%+2.1pp	-2.8%-6.2pp
Earnings yield	3.8%—	3.4%—	——	——	——

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Questions, answered.

What are Vertex Pharmaceuticals's profit margins?: Vertex Pharmaceuticals (VRTX) runs a 86.2% gross margin and a 38.3% operating margin, with a 35.5% net margin.
Where do Vertex Pharmaceuticals's ratios come from?: Every ratio is computed from Vertex Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.