What are Castle Biosciences's profit margins?

Castle Biosciences (CSTL) runs a 77.9% gross margin and a -9.8% operating margin, with a -3.8% net margin.

Where do Castle Biosciences's ratios come from?

Every ratio is computed from Castle Biosciences's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Castle Biosciences CSTL Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	TTM Q1 '26	TTM Q4 '25	TTM Q3 '25	TTM Q2 '25	TTM Q1 '25
Profitability
Gross margin	77.9%-1.5pp	79.4%-0.6pp	79.9%-1.1pp	81%-0.9pp	81.9%+0.1pp
Operating margin	-9.8%+2.6pp	-12.4%-2.3pp	-10.2%-3.5pp	-6.7%-2.7pp	-4%-6.6pp
Net margin	-3.8%+3.2pp	-7%-3.5pp	-3.6%-0.8pp	-2.7%-1.3pp	-1.5%-7.0pp
EBITDA margin	-5.4%-4.8pp	-0.6%-2.9pp	2.3%-3.3pp	5.6%-2.6pp	8.2%+0.8pp
Free cash flow margin	1.3%-6.9pp	8.2%+0.8pp	7.4%—	——	——
Returns
Return on equity	-2.8%+2.4pp	-5.2%-2.5pp	-2.7%-0.5pp	-2.2%-1.0pp	-1.2%-5.5pp
Return on assets	-2.4%+1.9pp	-4.4%-2.1pp	-2.3%-0.4pp	-1.8%-0.8pp	-1.1%-4.8pp
Return on invested capital	-8.2%+3.1pp	-11.4%-2.5pp	-8.8%-2.9pp	-6%-2.1pp	-3.8%-6.4pp
Efficiency
Asset turnover	0.6×0.0×	0.6×0.0×	0.6×0.0×	0.7×-0.1×	0.7×0.0×
Inventory turnover	8.7×+1.0×	7.7×-1.3×	9.1×+1.0×	8×-0.6×	8.7×+1.2×
Liquidity
Current ratio	6.7×+1.5×	5.3×-1.2×	6.5×-0.4×	6.9×-2.5×	9.4×+2.1×
Quick ratio	6.5×+1.4×	5.1×-1.2×	6.3×-0.4×	6.7×-2.5×	9.2×+2.1×
Cash ratio	1.3×-0.4×	1.7×+0.2×	1.5×-0.1×	1.6×-0.8×	2.4×0.0×
Leverage
Debt-to-equity	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Debt-to-assets	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Interest coverage	-164×+334×	-497.8×-271×	-226.8×-157×	-69.6×-45.9×	-23.8×-38.8×
Per Share
Book value per share	$15.44-5.0%	$16.24+1.1%	$16.06+4.2%	$15.41+0.1%	$15.39-1.2%
Valuation
Market capitalization	$694.86M+29.9%	$1.14B+71.9%	$660.52M+19.4%	$553.19M-3.1%	$570.85M-23.5%
Enterprise value	$667.82M+41.8%	$1.06B+72.5%	$612.1M+20.4%	$508.31M+0.3%	$507.01M-22.4%
Price / sales	2×+0.5×	3.3×+1.4×	1.9×+0.3×	1.6×0.0×	1.6×-0.6×
Price / book	1.5×+0.3×	2.4×+1.0×	1.4×+0.2×	1.2×-0.1×	1.3×-0.3×
EV / sales	2×+0.6×	3.1×+1.3×	1.8×+0.3×	1.5×0.0×	1.5×-0.5×
Free cash flow yield	0.7%-7.2pp	2.5%-1.3pp	3.8%—	——	——
Earnings yield	-1.8%-0.9pp	-2.1%-0.3pp	-1.9%-0.1pp	-1.7%-0.8pp	-0.9%-3.3pp

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Questions, answered.

What are Castle Biosciences's profit margins?: Castle Biosciences (CSTL) runs a 77.9% gross margin and a -9.8% operating margin, with a -3.8% net margin.
Where do Castle Biosciences's ratios come from?: Every ratio is computed from Castle Biosciences's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.