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EBITDA margin at other companies

Bristol-Myers Squibb logo
Bristol-Myers SquibbBMY
27.2%-2.2pp
Eli Lilly logo
Eli LillyLLY
45.9%+14.4pp
Amgen logo
AmgenAMGN
41.5%+3.4pp
Incyte logo
IncyteINCY
31.8%+25.8pp
AbbVie logo
AbbVieABBV
37.3%
Spyre Therapeutics, Inc. logo
Spyre Therapeutics, Inc.SYRE
-17,462.5%-18,885pp

Other financials

Income statement

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Revenue$56.4M+99.0%
Operating income-$3.6M+81.1%
Net income$3.8M+132%
EPS (diluted)$0.05+126%

Balance sheet

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Cash & equivalents$193.7M+38.7%
Total debt$9.8M-13.9%
Total equity$655.5M-4.9%
Total assets$697.5M-6.0%

Cash flow

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Operating cash flow-$48.9M-139%
CapEx$215.0K-60.6%
Free cash flow-$49.2M-139%

Valuation

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Market cap$7.26B+127%
Enterprise value$7.07B+130%
P/S98×+82.6×

Profitability

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Operating margin-192.4%-205pp
Net margin-154.9%-182pp
FCF margin-12,264.3%-12,527pp

Returns & leverage

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Return on equity-17.1%-26.1pp
Debt / equity0.0×
Current ratio17.8×+0.5×

Where this comes from

Calculated from Protagonist Therapeutics’s reported figures.

Based on trailing twelve months.

The official record: Protagonist Therapeutics’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Protagonist Therapeutics's EBITDA margin?
Protagonist Therapeutics (PTGX) reported EBITDA margin of -190.4% in Q1 2026.
How has Protagonist Therapeutics's EBITDA margin changed year-over-year?
Protagonist Therapeutics's EBITDA margin decreased by 1510.4% year-over-year, from 13.5% to -190.4%.
What is the long-term trend for Protagonist Therapeutics's EBITDA margin?
Over 3 years (2021 to 2025), Protagonist Therapeutics's EBITDA margin has grown at a -9.3% compound annual growth rate (CAGR), from -457% to -340.9%.
What does EBITDA margin mean?
EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.