What are Vertex Pharmaceuticals's profit margins?

Vertex Pharmaceuticals (VRTX) runs a 86.2% gross margin and a 38.3% operating margin, with a 35.5% net margin.

Where do Vertex Pharmaceuticals's ratios come from?

Every ratio is computed from Vertex Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Vertex Pharmaceuticals VRTX Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	86.2%0.0pp	86.2%0.0pp	86.3%+0.2pp	86.1%+0.1pp	86%-0.1pp
Operating margin	38.3%+3.5pp	34.8%—	——	——	——
Net margin	35.5%+2.6pp	32.9%—	——	——	——
Returns
Return on equity	24.2%+1.7pp	22.5%—	——	——	——
Return on invested capital	26.8%+2.5pp	24.3%-1.4pp	25.7%-1.3pp	27%+32.4pp	-5.3%-4.8pp
Efficiency
Asset turnover	0.5×0.0×	0.5×0.0×	0.5×0.0×	0.5×0.0×	0.5×0.0×
Liquidity
Current ratio	3×+0.1×	2.9×+0.5×	2.4×-0.2×	2.5×-0.1×	2.6×0.0×
Leverage
Debt-to-equity	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Net debt / EBITDA	-0.7×0.0×	-0.7×0.0×	-0.7×+0.1×	-0.8×—	——
Per Share
Book value per share	$75.54+4.4%	$72.35+7.6%	$67.23+1.3%	$66.34+4.4%	$63.57-0.1%
Valuation
Market capitalization	$113.44B-1.4%	$115.03B+14.6%	$100.41B-13.2%	$115.63B-7.1%	$124.5B+20.0%
Price / earnings	26.1×-2.9×	29.1×—	——	——	——
Price / sales	9.3×-0.3×	9.6×+1.0×	8.6×-1.6×	10.1×-1.1×	11.2×+1.8×
Price / book	5.9×-0.3×	6.2×+0.4×	5.8×-0.9×	6.7×-0.8×	7.5×+1.2×
EV / EBITDA	22.4×-3.1×	25.5×+3.0×	22.6×-3.9×	26.5×—	——

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Questions, answered.

What are Vertex Pharmaceuticals's profit margins?: Vertex Pharmaceuticals (VRTX) runs a 86.2% gross margin and a 38.3% operating margin, with a 35.5% net margin.
Where do Vertex Pharmaceuticals's ratios come from?: Every ratio is computed from Vertex Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.