What are Alnylam Pharmaceuticals's profit margins?

Alnylam Pharmaceuticals (ALNY) runs a 81.0% gross margin and a 17.5% operating margin, with a 11.7% net margin.

Where do Alnylam Pharmaceuticals's ratios come from?

Every ratio is computed from Alnylam Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Alnylam Pharmaceuticals ALNY Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	81%-5.3pp	81.8%-4.6pp	84%-2.8pp	83.9%-4.5pp	86.3%+0.3pp
Operating margin	17.5%+22.5pp	13.5%+21.4pp	8.2%+17.2pp	-7.3%-11.7pp	-4.9%+3.9pp
Net margin	11.7%+21.5pp	7.5%+19.9pp	2.6%+18.4pp	-11.4%-8.3pp	-9.8%+6.8pp
EBITDA margin	18.8%+21.3pp	15%+20.4pp	10%+16.3pp	-5%-11.8pp	-2.5%+3.6pp
Free cash flow margin	15%+18.3pp	12.5%+14.4pp	6.9%—	-2.1%—	-3.3%—
Returns
Return on equity	66.9%—	65%—	62.2%—	——	——
Return on assets	10.8%+16.5pp	6%+12.9pp	1.8%+10.1pp	-6.5%-4.6pp	-5.7%+3.5pp
Efficiency
Asset turnover	0.9×+0.3×	0.8×+0.2×	0.7×+0.2×	0.6×-0.1×	0.6×0.0×
Inventory turnover	10.9×+6.9×	8.4×+4.7×	6.8×+3.6×	5.1×+2.1×	4×+1.5×
Liquidity
Current ratio	3.1×+0.1×	2.8×0.0×	2.5×-0.2×	2.8×-0.2×	3×-0.1×
Quick ratio	3.1×+0.1×	2.7×0.0×	2.5×-0.2×	2.7×-0.2×	3×-0.1×
Cash ratio	1.3×+0.3×	1.1×+0.3×	1×+0.1×	0.9×-0.1×	1×+0.2×
Leverage
Debt-to-equity	0.2×-0.4×	0.3×-3.7×	1.1×-7.5×	1.1×—	0.6×—
Debt-to-assets	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Net debt / EBITDA	-1.8×—	-2.5×—	-3.8×—	——	——
Interest coverage	3.4×+4.1×	2.4×+3.7×	1.5×+2.9×	-1×-1.8×	-0.7×+0.7×
Per Share
Book value per share	$7.78+137%	$5.86+1,015%	$1.70+577%	$1.92+8,027%	$3.29+289%
Valuation
Market capitalization	$43.88B+25.6%	$52.54B+73.1%	$59.77B+69.3%	$42.38B+37.9%	$34.95B+85.7%
Enterprise value	$42.43B+24.1%	$51.15B+72.5%	$58.55B+69.8%	$41.53B+38.2%	$34.2B+85.7%
Price / earnings	87.4×—	188.9×—	721.9×—	——	——
Price / sales	10.2×-4.6×	14.1×+0.6×	18.6×+1.8×	17.2×+4.1×	14.9×+5.5×
Price / book	40.8×-41.2×	66.6×-386×	255.6×-836×	169.1×—	82×—
EV / EBITDA	52.6×—	91.8×—	182.4×—	——	——
EV / sales	9.9×-4.7×	13.8×+0.6×	18.2×+1.8×	16.9×+4.1×	14.6×+5.4×
Free cash flow yield	1.5%+1.7pp	0.9%+1.0pp	0.4%—	-0.1%—	-0.2%—
Earnings yield	1.1%+1.8pp	0.5%+1.4pp	0.1%+1.1pp	-0.7%-0.4pp	-0.7%+1.1pp

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Questions, answered.

What are Alnylam Pharmaceuticals's profit margins?: Alnylam Pharmaceuticals (ALNY) runs a 81.0% gross margin and a 17.5% operating margin, with a 11.7% net margin.
Where do Alnylam Pharmaceuticals's ratios come from?: Every ratio is computed from Alnylam Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.