What are Castle Biosciences's profit margins?

Castle Biosciences (CSTL) runs a 77.9% gross margin and a -9.8% operating margin, with a -3.8% net margin.

Where do Castle Biosciences's ratios come from?

Every ratio is computed from Castle Biosciences's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Castle Biosciences CSTL Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	77.9%-4.1pp	79.4%-2.5pp	79.9%-2.0pp	81%-0.9pp	81.9%+1.4pp
Operating margin	-9.8%-5.8pp	-12.4%-15.0pp	-10.2%-9.8pp	-6.7%-1.2pp	-4%+12.7pp
Net margin	-3.8%-2.3pp	-7%-12.5pp	-3.6%-5.5pp	-2.7%-1.7pp	-1.5%+10.8pp
EBITDA margin	-5.4%-13.6pp	-0.6%-8.0pp	2.3%-1.7pp	5.6%+6.5pp	8.2%+19.9pp
Free cash flow margin	1.3%-10.7pp	8.2%-2.8pp	7.4%—	10%—	12%—
Returns
Return on equity	-2.8%-1.6pp	-5.2%-9.5pp	-2.7%-4.2pp	-2.2%-1.4pp	-1.2%+6.6pp
Return on assets	-2.4%-1.4pp	-4.4%-8.1pp	-2.3%-3.5pp	-1.8%-1.2pp	-1.1%+5.9pp
Return on invested capital	-8.2%-4.4pp	-11.4%-13.9pp	-8.8%-8.5pp	-6%-1.2pp	-3.8%+9.5pp
Efficiency
Asset turnover	0.6×-0.1×	0.6×-0.1×	0.6×0.0×	0.7×0.0×	0.7×+0.2×
Inventory turnover	8.7×0.0×	7.7×+0.2×	9.1×-0.1×	8×+0.7×	8.7×+0.6×
Liquidity
Current ratio	6.7×-2.6×	5.3×-2.0×	6.5×-1.3×	6.9×-1.3×	9.4×+0.1×
Quick ratio	6.5×-2.7×	5.1×-2.0×	6.3×-1.3×	6.7×-1.2×	9.2×+0.2×
Cash ratio	1.3×-1.1×	1.7×-0.7×	1.5×-0.6×	1.6×-0.6×	2.4×-0.2×
Leverage
Debt-to-equity	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Debt-to-assets	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×0.0×
Interest coverage	-164×-140×	-497.8×-513×	-226.8×-225×	-69.6×-14.9×	-23.8×+1,973×
Per Share
Book value per share	$15.44+0.3%	$16.24+4.3%	$16.06+7.1%	$15.41+4.5%	$15.39+5.1%
Valuation
Market capitalization	$694.86M+29.9%	$1.14B+52.1%	$660.52M-16.5%	$553.19M-8.0%	$570.85M-6.1%
Enterprise value	$667.82M+41.8%	$1.06B+61.6%	$612.1M-15.3%	$508.31M-6.0%	$507.01M-7.8%
Price / sales	2×+0.5×	3.3×+1.1×	1.9×-0.6×	1.6×-0.5×	1.6×-0.8×
Price / book	1.5×+0.3×	2.4×+0.8×	1.4×-0.4×	1.2×-0.2×	1.3×-0.2×
EV / sales	2×+0.6×	3.1×+1.1×	1.8×-0.5×	1.5×-0.4×	1.5×-0.7×
Free cash flow yield	0.7%-7.2pp	2.5%-2.4pp	3.8%—	6.2%—	7.3%—
Earnings yield	-1.8%-0.9pp	-2.1%-4.6pp	-1.9%-2.6pp	-1.7%-1.2pp	-0.9%+4.2pp

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Questions, answered.

What are Castle Biosciences's profit margins?: Castle Biosciences (CSTL) runs a 77.9% gross margin and a -9.8% operating margin, with a -3.8% net margin.
Where do Castle Biosciences's ratios come from?: Every ratio is computed from Castle Biosciences's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.