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Spyre Therapeutics, Inc.

SYRE

Spyre Therapeutics is a clinical-stage biotechnology company focused on developing next-generation, long-acting antibody therapies for inflammatory bowel disease (IBD) and rheumatic diseases.

Market cap
$8.69B+733%
Net income-$179.4M+14.1%
EPS (diluted)-$2.12+30.7%
Trailing twelve months · change vs. prior year

Earnings

Next report

Aug 4, 2026 (In 6 days)
EPS estimate-$0.71

Financials

Q1 2026

Income statement

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Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%

Valuation & ratios

Valuation

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Market cap$8.69B+733%

Returns & leverage

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Return on equity-31.1%-10.7pp
Current ratio+0.9×

Competitors

Profile

Spyre Therapeutics is a clinical-stage biotechnology company focused on developing next-generation, long-acting antibody therapies for inflammatory bowel disease (IBD) and rheumatic diseases. The company leverages half-life extension technologies and high-concentration formulations to create monotherapies and fixed-dose combinations designed for quarterly or twice-annual subcutaneous dosing. Its core value proposition lies in improving patient outcomes and compliance through superior potency, optimized pharmacokinetics, and multi-pathway combination treatments.

Competitive position

Clinical-stage innovator focused on redefining the standard of care in IBD through extended half-life antibodies and novel combination regimens.

GeographiesUnited States, Global
Customer segmentsPatients, Healthcare providers
Business modelR&D intensive, IP licensing
SuppliersContract Manufacturing Organizations (CMOs), Contract Research Organizations (CROs), Cell line licensing providers, Raw material suppliers
CustomersSpecialty pharmacies, Hospitals, Infusion centers, Third-party payors
Listed2016
Employees30.0
CEOCameron Turtle
Websitespyre.com
FilingsSEC EDGAR

Questions, answered.

What is Spyre Therapeutics, Inc.'s market cap?
Spyre Therapeutics, Inc. (SYRE) has a market capitalization of $8.7B and trades on NASDAQ.
Who are Spyre Therapeutics, Inc.'s competitors?
Spyre Therapeutics, Inc.'s key competitors include Johnson & Johnson, AbbVie, Pfizer, and others. These companies compete in similar markets and product categories.
Who does Spyre Therapeutics, Inc. partner with?
Spyre Therapeutics, Inc.'s notable partners include Paragon Therapeutics, WuXi Biologics.
What subsidiaries does Spyre Therapeutics, Inc. have?
Spyre Therapeutics, Inc.'s subsidiaries include Parapyre.
Where is Spyre Therapeutics, Inc. headquartered?
Spyre Therapeutics, Inc. is headquartered in United States of America and employs approximately 30 people. It has been publicly traded since 2016.