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Other financials

Income statement

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Revenue-
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.2B+854%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:OperatingIncomeLoss.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemThree Months Ended March 31, 20262025
General and administrative (2)15,23011,944
Gain on sale of in-process research and development asset(30,000)
Total operating expenses45,64153,567
Loss from operations(45,641)(53,567)
Other (expense) income:
Interest income6,9956,493
Other (expense) income, net(30,359)2,286
Total other (expense) income(23,364)8,779

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s operating income?
Spyre Therapeutics, Inc. (SYRE) reported operating income of -$45.64M in Q1 2026.
How has Spyre Therapeutics, Inc.'s operating income changed year-over-year?
Spyre Therapeutics, Inc.'s operating income increased by 14.8% year-over-year, from -$53.57M to -$45.64M.
What is the long-term trend for Spyre Therapeutics, Inc.'s operating income?
Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s operating income has grown at a 33.7% compound annual growth rate (CAGR), from -$65.65M to -$209.56M.
What does operating income mean?
Gross profit minus all operating expenses (SG&A, R&D, D&A). Measures the profit from core business operations before interest, taxes, and non-operating items.

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