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Discontinued — last reported Q4 '24

Free cash flow at other companies

Bristol-Myers Squibb logo
Bristol-Myers SquibbBMY
$757M-55.3%
Eli Lilly logo
Eli LillyLLY
$3.01B+1,828%
Pfizer logo
PfizerPFE
$2.18B+23.0%
Johnson & Johnson logo
Johnson & JohnsonJNJ
$1.47B-56.6%
Merck & Co. logo
Merck & Co.MRK
$2.93B+150%
AbbVie logo
AbbVieABBV
$3.56B+155%

Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Calculated from Spyre Therapeutics, Inc.’s reported figures.

The official record: Spyre Therapeutics, Inc.’s 10-K, filed February 19, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s free cash flow?
Spyre Therapeutics, Inc. (SYRE) reported free cash flow of -$39.35M in Q4 2024.
How has Spyre Therapeutics, Inc.'s free cash flow changed year-over-year?
Spyre Therapeutics, Inc.'s free cash flow decreased by 26.8% year-over-year, from -$31.04M to -$39.35M.
What is the long-term trend for Spyre Therapeutics, Inc.'s free cash flow?
Over 2 years (2021 to 2024), Spyre Therapeutics, Inc.'s free cash flow has grown at a 67.1% compound annual growth rate (CAGR), from -$56.34M to -$157.41M.
What does free cash flow mean?
Free cash flow represents the cash generated by a company after accounting for cash outflows to support operations and maintain or expand its capital asset base. It serves as a critical indicator of a company's ability to fund organic growth, pay down debt, or return capital to shareholders without relying on external financing.