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Net margin at other companies

Bristol-Myers Squibb logo
Bristol-Myers SquibbBMY
15%+3.8pp
Eli Lilly logo
Eli LillyLLY
35%+12.3pp
Pfizer logo
PfizerPFE
15.7%
Johnson & Johnson logo
Johnson & JohnsonJNJ
21.8%-2.6pp
Merck & Co. logo
Merck & Co.MRK
13.6%-13.7pp
AbbVie logo
AbbVieABBV
5.8%-1.5pp

Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Calculated from Spyre Therapeutics, Inc.’s reported figures.

Based on trailing twelve months.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 8, 2025, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s net margin?
Spyre Therapeutics, Inc. (SYRE) reported net margin of -52,939.7% in Q1 2024.
How has Spyre Therapeutics, Inc.'s net margin changed year-over-year?
Spyre Therapeutics, Inc.'s net margin decreased by 692.7% year-over-year, from -6,678.2% to -52,939.7%.
What is the long-term trend for Spyre Therapeutics, Inc.'s net margin?
Over 2 years (2021 to 2023), Spyre Therapeutics, Inc.'s net margin has grown at a 943.5% compound annual growth rate (CAGR), from -351.1% to -38,238.1%.
What does net margin mean?
The share of every sales dollar that becomes bottom-line profit.
How do you interpret net margin?
Higher is better, but net margin mixes operating performance with financing and tax effects and one-off items — read it alongside operating margin to separate the operating story from the rest.
How does net margin compare across companies?
Comparable across peers but sensitive to leverage and tax structure; two operationally identical firms can show different net margins purely from financing.